Coiled Coils – A Model System for the 21st Century
| Autor: | Jens Bassler, Andrei N. Lupas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Models
Molecular 0301 basic medicine Coiled coil Viral Membrane Fusion Computer science Protein design Proteins Model system Nanotechnology 010402 general chemistry 01 natural sciences Biochemistry Protein Structure Secondary 0104 chemical sciences 03 medical and health sciences 030104 developmental biology Mechanical stability Humans Biochemical engineering Molecular Biology |
| Zdroj: | Trends in Biochemical Sciences. 42:130-140 |
| ISSN: | 0968-0004 |
| Popis: | α-Helical coiled coils were described more than 60 years ago as simple, repetitive structures mediating oligomerization and mechanical stability. Over the past 20 years, however, they have emerged as one of the most diverse protein folds in nature, enabling many biological functions beyond mechanical rigidity, such as membrane fusion, signal transduction, and solute transport. Despite this great diversity, their structures can be described by parametric equations, making them uniquely suited for rational protein design. Far from having been exhausted as a source of structural insight and a basis for functional engineering, coiled coils are poised to become even more important for protein science in the coming decades. |
| Databáze: | OpenAIRE |
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