Effects of Enterococcus sp. isolated from deep seawater on inhibition of allergic responses in mice
| Autor: | Atsushi Hayashi, Masatoshi Kondoh, Lei Cheng, Takashi Shimada, Chie Motonaga, Mariko Okamori, Tadao Enomoto |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Hypersensitivity
Immediate Allergy Ratón Cryptomeria Enterococcus faecium Medicine (miscellaneous) Immunoglobulin E medicine.disease_cause Microbiology Leukocyte Count Mice Allergen Oral administration Immunopathology Anti-Allergic Agents medicine Animals Seawater Anaphylaxis Antigens Bacterial Mice Inbred BALB C Nutrition and Dietetics Microbial Viability biology Dose-Response Relationship Drug Eosinophil Allergens medicine.disease biology.organism_classification Eosinophils medicine.anatomical_structure Models Animal biology.protein Pollen Female Water Microbiology Injections Intraperitoneal |
| Zdroj: | The British journal of nutrition. 102(1) |
| ISSN: | 1475-2662 |
| Popis: | The objective of the present study was to assess the effects ofEnterococcussp. strain TN-3 isolated from deep seawater on inhibition of eosinophil accumulation, IgE production and active cutaneous anaphylaxis (ACA). We investigated the effects of viable and non-viable TN-3 on allergen-induced peritoneal eosinophil accumulation in mice. Viable (5·4 × 1010colony-forming units per 60 mg) or non-viable TN-3 (60 mg) was orally administered to BALB/c mice that had been sensitised with the cedar pollen (Cryptomeria japonica) allergen. Oral administration of non-viable TN-3 was effective in suppressing eosinophil accumulation while viable TN-3 was ineffective. We also examined the dose–response relationship for non-viable TN-3 in regard to eosinophil accumulation, IgE production and ACA in allergen-primed mice. Non-viable TN-3 was orally administered at doses of 15 mg (low dose), 30 mg (medium dose) and 60 mg (high dose) to BALB/c mice that had been sensitised with cedar pollen allergen. The anti-allergic effects expressed as inhibition of eosinophil accumulation, IgE production and ACA were found at the low and high doses, but not at the medium dose. These results suggest that non-viable TN-3 exhibited anti-allergic effects at doses of 15 and 60 mg. |
| Databáze: | OpenAIRE |
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