Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19

Autor: Hanchun Chen, Jiangzhou Peng, Baixu Zhou, Jiewen Fu, Kyathegowdanadoddi Srinivasa Balaji, Junjiang Fu, Xiaoyan Liu, Lianmei Zhang, Chunli Wei
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Kidney
Pathogenesis
Mice
0302 clinical medicine
Databases
Genetic
Testis
Lung
Cancer
Regulation of gene expression
Liver Neoplasms
General Medicine
Kidney Neoplasms
medicine.anatomical_structure
Liver
030220 oncology & carcinogenesis
Host-Pathogen Interactions
Spike Glycoprotein
Coronavirus
Receptors
Virus
Immunohistochemistry
Female
Original Article
Angiotensin-Converting Enzyme 2
Coronavirus Infections
Liver cancer
hormones
hormone substitutes
and hormone antagonists
Protein Binding
Signal Transduction
Adult
Pneumonia
Viral
RNA-sequencing
Peptidyl-Dipeptidase A
Biology
Betacoronavirus
03 medical and health sciences
medicine
Genetics
Animals
Humans
Mammary Glands
Human
Pandemics
Survival rate
Molecular Biology
SARS-CoV-2
Sequence Analysis
RNA
COVID-19
ACE2 gene
Kidney metabolism
medicine.disease
Survival Analysis
Immunohistochemistry (IHC)
030104 developmental biology
Gene Expression Regulation
Cancer research
Zdroj: Molecular Biology Reports
ISSN: 1573-4978
0301-4851
DOI: 10.1007/s11033-020-05478-4
Popis: The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances for this gene in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from different tissues of mouse and semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) was carried out. Immunohistochemistry expression profiles in normal tissues and cancer tissues and TCGA survival analysis in renal and liver cancer were conducted. ACE2 was highly conserved in different species. In normal tissues, ACE2 expression distributions were organ-specific, mainly in the kidney, male testis and female breast, and cardiovascular and gastrointestinal systems. High level of expression in testis, cardiovascular and gastrointestinal system indicated that SARS-CoV-2 might not only attack the lungs, but also affect other organs, particularly the testes, thus it may severely damage male sexual development for younger male and lead to infertility in an adult male, if he contracted COVID-19. On the other side, high expression of ACE2 was correlated with increased survival rate in renal and liver cancer, indicating that ACE2 is a prognostic marker in both renal cancer and liver cancers. Thus, the ACE2 is a functional receptor for SARS-CoV-2 and has a potential anti-tumor role in cancer. Taken together, this study may not only provide potential clues for further medical pathogenesis of COVID-19 and male fertility, but also indicate the clinical significance of the role of the ACE2 gene in cancer.
Databáze: OpenAIRE
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