Is the blood of a surgeon performing HIPEC contaminated by irinotecan, its major metabolites and platinum compounds?
| Autor: | Raphaël Delépée, Jean-Marc Guilloit, Stéphanie Lagadu, Sophie Ndaw, Agnès Palix, Mathieu Melczer, Simon Rodier, Guillaume Saint-Lorant |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
HIPEC Plasma samples business.industry Blood contamination Platinum compounds Context (language use) Contamination 030210 environmental & occupational health Gastroenterology antineoplastic drugs Irinotecan 03 medical and health sciences 0302 clinical medicine blood contamination 030220 oncology & carcinogenesis Internal medicine Internal Medicine medicine Hyperthermic intraperitoneal chemotherapy business Active metabolite Research Article medicine.drug |
| Zdroj: | Pleura and Peritoneum |
| ISSN: | 2364-768X 2364-7671 |
| Popis: | Objectives Hyperthermic intraperitoneal chemotherapy (HIPEC) is a beneficial surgical technique for patients, but the surgeons are being exposed to cytotoxic drugs. Few biomonitoring studies were led on blood samples in the context of HIPEC. This study aimed to evaluate the surgeon’s plasmatic and red blood cell (RBC) contamination by irinotecan, two of its major metabolites and platinum compounds. Methods HIPEC procedures performed using the coliseum techniques were observed between September 2015 and April 2018 in a French comprehensive cancer center. Irinotecan and its metabolites SN-38 and APC were dosed by UHPLC with a limit of quantification determined at 50 pg/mL. Platinum compounds were dosed by inductively coupled plasma mass spectrometry with a limit of quantification determined at 16 pg/mL. Results Despite collective and personal protective equipment, 80% of plasma samples were contaminated by irinotecan and 33% by platinum compounds out of 21. The results showed that the surgeon was contaminated after HIPEC and even after a period of HIPEC inactivity. Nineteen percent of plasmatic samples and 45% of RBC samples were contaminated by SN-38, the active metabolite of irinotecan. APC was only found in some RBC samples (33%). Conclusions Even if this study shows blood contamination by irinotecan, two of its major metabolites (including active SN-38) and platinum compounds both in the plasma and RBC of a surgeon performing the HIPEC procedures, further studies should be performed to confirm these results. Additional studies should be carried out to further investigate the contamination in the context of HIPEC and more broadly in the hospital. |
| Databáze: | OpenAIRE |
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