A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273

Autor:	Boyang Yu, You-Gen Chen, Ji-Hua Liu, Yi-Jun Chen
Rok vydání:	2005
Předmět:	Ketone Magnetic Resonance Spectroscopy Spectrophotometry Infrared Stereochemistry Metabolite Clinical Biochemistry Pharmaceutical Science Biochemistry Mass Spectrometry Terpene chemistry.chemical_compound Biotransformation Anti-Infective Agents Drug Discovery medicine Organic chemistry Artemisinin Molecular Biology chemistry.chemical_classification biology Streptomycetaceae Organic Chemistry Streptomyces griseus General Medicine biology.organism_classification Artemisinins chemistry Molecular Medicine Actinomycetales Sesquiterpenes Derivative (chemistry) medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 16(7)
ISSN:	0960-894X
Popis:	A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product was fully elucidated by various spectroscopic techniques, and the mechanism of generating such novel metabolite is also discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12573ebfd7b0d726a2b69560fafa158 https://pubmed.ncbi.nlm.nih.gov/16434191 Zobrazit plný text záznamu Full Text from ScienceDirect