Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers
| Autor: | Hong-Beom Park, Ju-Won Kim, Kwang-Hyun Baek |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Protein Folding
Cellular differentiation Review Catalysis Deubiquitinating enzyme lcsh:Chemistry Inorganic Chemistry Glycogen Synthase Kinase 3 Ubiquitin Neoplasms Cell polarity Animals Humans cancer Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Wnt Signaling Pathway Spectroscopy biology deubiquitinating enzymes Organic Chemistry Wnt signaling pathway Ubiquitination General Medicine Wnt signaling Computer Science Applications Ubiquitin ligase Cell biology Gene Expression Regulation Neoplastic inhibitor Ubiquitins small molecules lcsh:Biology (General) lcsh:QD1-999 Mutation biology.protein Protein Processing Post-Translational Deubiquitination Protein Binding |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 3904, p 3904 (2020) |
| ISSN: | 1422-0067 |
| Popis: | The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. Dysregulation of Wnt signaling is associated with various diseases such as cancer, aging, Alzheimer’s disease, metabolic disease, and pigmentation disorders. Numerous studies entailing the Wnt signaling pathway have been conducted for various cancers. Diverse signaling factors mediate the up- or down-regulation of Wnt signaling through post-translational modifications (PTMs), and aberrant regulation is associated with several different malignancies in humans. Of the numerous PTMs involved, most Wnt signaling factors are regulated by ubiquitination and deubiquitination. Ubiquitination by E3 ligase attaches ubiquitins to target proteins and usually induces proteasomal degradation of Wnt signaling factors such as β-catenin, Axin, GSK3, and Dvl. Conversely, deubiquitination induced by the deubiquitinating enzymes (DUBs) detaches the ubiquitins and modulates the stability of signaling factors. In this review, we discuss the effects of ubiquitination and deubiquitination on the Wnt signaling pathway, and the inhibitors of DUBs that can be applied for cancer therapeutic strategies. |
| Databáze: | OpenAIRE |
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