Spatial Distribution and Burden of Emerging Arboviruses in French Guiana
| Autor: | Anne Lavergne, Jean-François Carod, Camille Fritzell, Léna Berthelot, Sarah Bailly, Claude Flamand, Sandrine Fernandes-Pellerin, Antoine Enfissi, Dominique Rousset, Jean-Claude Manuguerra, Sarrah Ben Achour, Simon Cauchemez, Félix Djossou, Jessica Vanhomwegen, Nathanaël Hozé, Mona Saout, Henrik Salje |
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| Přispěvatelé: | Unité d'Epidémiologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris], University of Cambridge [UK] (CAM), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], This study was supported by the European Regional Development Fund under EPI-ARBO grant agreement GY0008695, the Regional Health Agency of French Guiana, and the National Center of Spatial Studies. C.F. (Claude Flamand) acknowledges financial support from the Centre National d’Etudes Spatiales-Terre solide, Océan, Surfaces Continentales, Atmosphère fund (grant number CNES-TOSCA-4800000720) and funding from Calmette and Yersin allocated by the Pasteur Institut Department of International Affairs. S.C. acknowledges financial support from the AXA Research Fund, the Investissement d’Avenir program, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases program (grant number ANR-10-LABX-62-IBEID), the Models of Infectious Disease Agent Study of the National Institute of General Medical Sciences, the INCEPTION project (PIA/ANR-16-CONV-0005), and the European Union’s Horizon 2020 research and innovation program under ZIKAlliance grant agreement number 734548., We thank Laure Garancher from the Ink Link Association, the coordination department of Health centers and all health centers, collaborators and field workers involved in the Arbovirus Epidemiologic Survey (EPI-ARBO) project. We also thank all biological and technical staff from the Arbovirus National Reference Center for their valuable contributions to the laboratory analyses., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 734548,ZIKAlliance(2016), Rousset, Dominique [0000-0002-1473-3147], Fritzell, Camille [0000-0002-4324-1109], Hozé, Nathanaël [0000-0002-3977-8966], Vanhomwegen, Jessica [0000-0002-7879-1485], Salje, Henrik [0000-0003-3626-4254], Lavergne, Anne [0000-0002-5304-5574], Djossou, Félix [0000-0002-6761-0511], Cauchemez, Simon [0000-0001-9186-4549], Flamand, Claude [0000-0002-8064-445X], Apollo - University of Cambridge Repository, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Serotype Recombinant antigen viruses Antibodies Viral medicine.disease_cause Serology Dengue fever Dengue 0302 clinical medicine Cost of Illness Seroepidemiologic Studies [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] Prevalence Chikungunya Child education.field_of_study prevalence studies virus diseases Middle Aged arboviruses Zika Mayaro French Guiana QR1-502 3. Good health Infectious Diseases Child Preschool Female Adult Adolescent 030231 tropical medicine Population Arbovirus Infections Biology Microbiology Article Young Adult 03 medical and health sciences Virology medicine Humans Seroprevalence education Aged Demography medicine.disease Serum samples Cross-Sectional Studies 030104 developmental biology Immunoglobulin G |
| Zdroj: | Viruses Viruses, MDPI, 2021, 13 (7), pp.1299. ⟨10.3390/v13071299⟩ Viruses, 2021, 13 (7), pp.1299. ⟨10.3390/v13071299⟩ Viruses; Volume 13; Issue 7; Pages: 1299 Viruses, Vol 13, Iss 1299, p 1299 (2021) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13071299⟩ |
| Popis: | International audience; Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6–75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7–23.1), 23.3% (20.9–25.9) and 3.3% (2.7–4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns. |
| Databáze: | OpenAIRE |
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