Components of the Metabolic Syndrome in Early Childhood in Very-Low-Birth-Weight Infants
| Autor: | H N Lafeber, M. de Jong, Anneke Cranendonk, M.M. van Weissenbruch |
|---|---|
| Přispěvatelé: | Pediatric surgery, ICaR - Circulation and metabolism |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Endocrinology Diabetes and Metabolism medicine.medical_treatment Infant Premature Diseases law.invention Body Mass Index chemistry.chemical_compound Endocrinology Randomized controlled trial law Internal medicine medicine Humans Hypoglycemic Agents Infant Very Low Birth Weight Insulin Age of Onset Metabolic Syndrome Cholesterol business.industry Infant Newborn Standard of Care medicine.disease Europe Low birth weight Blood pressure chemistry Child Preschool Hyperglycemia Pediatrics Perinatology and Child Health Female Metabolic syndrome Age of onset medicine.symptom business Body mass index |
| Zdroj: | de Jong, M, Lafeber, H N, Cranendonk, A & van Weissenbruch, M M 2014, ' Components of the Metabolic Syndrome in Early Childhood in Very-Low-Birth-Weight Infants ', Hormone Research in Paediatrics, vol. 81, no. 1, pp. 43-49 . https://doi.org/10.1159/000355597 Hormone Research in Paediatrics, 81(1), 43-49. S. Karger AG |
| ISSN: | 1663-2818 |
| Popis: | Background/Aims: Term small-for-gestational-age and preterm born infants have an increased prevalence of metabolic syndrome components already in childhood. Data in very-low-birth-weight (VLBW) children are limited. We investigated the prevalence of metabolic syndrome components in VLBW infants at 2 years of corrected age. Methods: We included 38 children, participating in the Neonatal Insulin Replacement Therapy in Europe (NIRTURE) trial, a randomized controlled trial of early insulin therapy in VLBW infants. Metabolic syndrome components were defined as: body mass index SDS >2; blood pressure (systolic and/or diastolic) ≥90th percentile; triglycerides ≥0.98 mmol/l; high-density lipoprotein (HDL) cholesterol ≤1.03 mmol/l; glucose ≥5.6 mmol/l. Results: Two children (5%) had three metabolic syndrome components, 13 children (34%) had two components, and 11 children (29%) one component. 63% had raised blood pressure (prevalence higher in boys), 32% low HDL, and 30% high triglycerides (prevalence lower in early insulin group). In children with body mass index SDS Conclusions: VLBW infants already have a high prevalence of metabolic syndrome components at 2 years of corrected age. Early insulin treatment could have long-term benefits for some of these components. |
| Databáze: | OpenAIRE |
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