Will imaging change the diagnosis and management of giant cell arteritis?
| Autor: | Camelia Badea, Andra Chiriac, Cristian Băicuș |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Systemic inflammation 030218 nuclear medicine & medical imaging 03 medical and health sciences compression sign 0302 clinical medicine Internal medicine Biopsy medicine Halo sign Pathological 030203 arthritis & rheumatology medicine.diagnostic_test giant cell arteritis business.industry ultrasonography medicine.disease RC31-1245 halo sign Rheumatology Giant cell arteritis Temporal artery Radiology medicine.symptom business Systemic vasculitis |
| Zdroj: | Romanian Journal of Internal Medicine, Vol 57, Iss 4, Pp 341-344 (2019) |
| ISSN: | 2501-062X |
| Popis: | Giant cell arteritis is a common systemic vasculitis affecting the elderly, with maximum prevalence in the 7th decade of age, targeting aortic derived medium and large vessels of the neck and head. Diagnosis is established on a biopsy specimen of the temporal artery wall, through pathological confirmation of panarteritis, typically characterized by mononuclear cell infiltrate, with the 1990 ACR criteria often used in clinical practice. We present the case of a patient with a new onset headache and systemic inflammation, who did not fulfil the classical diagnostic criteria, nor did the temporal artery biopsy (TAB) provide a positive result. However, the ultrasonographical features, clinical evolution and response to corticosteroid therapy confirmed the diagnosis. This patient had bilateral presence of the halo sign on color duplex ultrasonography (CDUS), cited as a highly specific feature, when compared to the ACR criteria as a standard reference. We employed its positive likelihood-ratio (LR+) of 43 as previously estimated, while considering a low pre-test probability for a positive diagnosis (15%), to calculate a post-test probability of 88%, leading to our decision to treat him as having giant cell arteritis. Remission of the headache and rebound phenomena when tapered off steroid therapy substantially contributed to the positive diagnosis, underlining the importance of future studies needing to use clinical evolution as a reference standard. |
| Databáze: | OpenAIRE |
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