National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
| Autor: | Kirsten Hanke, Norbert Bannert, Alexandra Hofmann, Viviane Bremer, Barbara Bartmeyer, Andrea Hauser, Claudia Kuecherer |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Epidemiology business.industry Public Health Environmental and Occupational Health Human immunodeficiency virus (HIV) virus diseases Robert koch institute Drug resistance 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit medicine.disease_cause Virology Molecular analysis Men who have sex with men 03 medical and health sciences 030104 developmental biology Genotype medicine In patient business HIV drug resistance |
| Zdroj: | Eurosurveillance. 22 |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/1560-7917.es.2017.22.2.30436 |
| Popis: | To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p |
| Databáze: | OpenAIRE |
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