Safety and efficacy of imiquimod 5% cream in the treatment of penile genital warts in uncircumcised men when applied three times weekly or once per day
| Autor: | K Milde, M Carey-Yard, Harald Gollnick, A Eul, R Barasso, Uta Jappe, K Ward |
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| Rok vydání: | 2001 |
| Předmět: |
Sexually transmitted disease
medicine.medical_specialty Erythema Imiquimod Dermatology medicine.disease_cause Genital warts law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Pharmacology (medical) 030212 general & internal medicine Dosing 030505 public health business.industry Public Health Environmental and Occupational Health medicine.disease Surgery Regimen Infectious Diseases medicine.symptom Irritation 0305 other medical science business medicine.drug |
| Zdroj: | International Journal of STD & AIDS. 12:22-28 |
| ISSN: | 0956-4624 |
| DOI: | 10.1258/0956462011916695 |
| Popis: | This dose-escalation study was performed to evaluate safety and efficacy of imiquimod 5% cream in the treatment of uncircumcised men with penile warts associated with the foreskin. The cream was applied 3 times/week (n=34) or once per day (n=30) over 8 ± 2h. Imiquimod 5% cream was safe in both treatment groups. However, the 3 times/week regimen was better tolerated with a lower incidence of local skin reactions. In both groups, the 2 most frequently reported local skin reactions were erythema and erosion; they were more severe with the once-daily dosing. The most frequently reported application site reactions were burning, pruritus and irritation or pain (once-daily patients only). Total clearance was achieved in 62% of the patients in the 3 times/week group and by 57% in the once-daily group. Thus, imiquimod 5% cream administered 3 times/week was the optimal dosing regimen in the treatment of penile warts in uncircumcised men. |
| Databáze: | OpenAIRE |
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