Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin
| Autor: | Iracilda Zeppone Carlos, Maria Stella Gonçalves Raddi, Wagner Vilegas, Rodrigo Rezende Kitagawa |
|---|---|
| Přispěvatelé: | Universidade Federal do Espírito Santo (UFES), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Antifungal
medicine.drug_class naphthoquinone lcsh:RS1-441 Tumor cells Pharmacology medicine.disease Naphthoquinone Nitric oxide lcsh:Pharmacy and materia medica chemistry.chemical_compound chemistry Murine tumor medicine Macrophage 5-methoxy-3 4-dehydroxanthomegnin General Pharmacology Toxicology and Pharmaceutics Lung cancer Cytotoxicity immunomodulatory cytotoxic activity |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 21, Iss 6, Pp 1084-1088 (2011) Revista Brasileira de Farmacognosia v.21 n.6 2011 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Volume: 21, Issue: 6, Pages: 1084-1088, Published: 05 AUG 2011 SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0102-695X |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:57:50Z No. of bitstreams: 1 S0102-695X2011000600019.pdf: 778494 bytes, checksum: a0287e301b0ee45419f2ec427fe39f56 (MD5) Made available in DSpace on 2013-08-22T18:57:50Z (GMT). No. of bitstreams: 1 S0102-695X2011000600019.pdf: 778494 bytes, checksum: a0287e301b0ee45419f2ec427fe39f56 (MD5) Previous issue date: 2011-12-01 Made available in DSpace on 2013-09-30T18:07:17Z (GMT). No. of bitstreams: 2 S0102-695X2011000600019.pdf: 778494 bytes, checksum: a0287e301b0ee45419f2ec427fe39f56 (MD5) S0102-695X2011000600019.pdf.txt: 23455 bytes, checksum: 0ab9caaa86e2e146f7c5ae889475ef32 (MD5) Previous issue date: 2011-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:25:13Z No. of bitstreams: 2 S0102-695X2011000600019.pdf: 778494 bytes, checksum: a0287e301b0ee45419f2ec427fe39f56 (MD5) S0102-695X2011000600019.pdf.txt: 23455 bytes, checksum: 0ab9caaa86e2e146f7c5ae889475ef32 (MD5) Made available in DSpace on 2014-05-20T13:25:13Z (GMT). No. of bitstreams: 2 S0102-695X2011000600019.pdf: 778494 bytes, checksum: a0287e301b0ee45419f2ec427fe39f56 (MD5) S0102-695X2011000600019.pdf.txt: 23455 bytes, checksum: 0ab9caaa86e2e146f7c5ae889475ef32 (MD5) Previous issue date: 2011-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities. Universidade Federal do Espírito Santo (UFES) Departamento de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química de Araraquara Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química de Araraquara Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Farmacêuticas de Araraquara |
| Databáze: | OpenAIRE |
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