Cancer obscures extrapulmonary tuberculosis (EPTB) at a tertiary hospital in Northern Malawi
| Autor: | Chikondi Sharon Chimbatata, Paul Uchizi Kaseka, J. S. T. Wu, Pocha Samuel Kamudumuli, Balwani Chingatichifwe Mbakaya, Frank Watson Sinyiza, Master Chisale, Alfred Kayira |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Malawi medicine.medical_specialty Adolescent tuberculosis (TB) Epidemiology 030231 tropical medicine Human immunodeficiency virus (HIV) medicine.disease_cause Cohort Studies Diagnosis Differential Tertiary Care Centers Young Adult 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine medicine cancer Humans Tuberculosis 030212 general & internal medicine Child Retrospective Studies Original Paper Retrospective review business.industry Incidence (epidemiology) Extrapulmonary tuberculosis Infant Cancer obscures Middle Aged medicine.disease Extra-pulmonary tuberculosis (EPTB) Infectious Diseases Child Preschool Female Hiv status Differential diagnosis business Neck lymph nodes |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s095026882000254x |
| Popis: | Data on the prevalence of extrapulmonary tuberculosis (EPTB) patients are limited in many African countries including Malawi. We conducted a retrospective review of all histology reports for cancer suspected patients at Mzuzu Central Hospital (MZCH) between 2013 and 2018 to determine the proportion of EPTB cases among cancer suspected patients and characterised them epidemiologically. All reports with inconclusive findings were excluded. In total, 2214 reports were included in the review, 47 of which reported EPTB, representing 2.1% (95% CI 1.6−2.8). The incidence of EPTB was significantly associated with sex, age and HIV status. Men were more than twice (OR 2.1; 95% CI 1.2–3.9) as likely to have EPTB as women while those with HIV were more than six times (OR 6.4; 95% CI 1.7–24.8) as likely to have EPTB compared to those who were HIV-negative. EPTB demonstrated an inverse relationship with age. The highest proportion of EPTB was found from neck lymph nodes (10.3% (5.4–17.2)). A reasonable number of EPTB cases are diagnosed late or missed in Malawi's hospitals. There is a need for concerted efforts to increase EPTB awareness and likely come up with a policy to consider EPTB as a differential diagnosis in cancer suspected patients. |
| Databáze: | OpenAIRE |
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