Emerging role of RNA interference in immune cells engineering and its therapeutic synergism in immunotherapy
| Autor: | Israth Jahan Tuhin, Miao Miao, Xu Nan, Lei Yu, Jingwen Tan, Xiaowen Tang, Ariful Islam, Masuma Akter Monty, Depei Wu |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_treatment fungi Immunotherapy Biology Immune checkpoint RNAi Therapeutics Small hairpin RNA MicroRNAs 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Cancer immunotherapy RNA interference Neoplasms Cancer research medicine Humans Gene silencing RNA Interference RNA Small Interfering 030217 neurology & neurosurgery |
| Zdroj: | British Journal of Pharmacology. 178:1741-1755 |
| ISSN: | 1476-5381 0007-1188 |
| DOI: | 10.1111/bph.15414 |
| Popis: | RNAi effectors (e.g., siRNA, shRNA, and miRNA) can efficiently trigger the silencing of specific genes, and its genomic alteration functions allowed to pursue clinical trials in distinct areas, including infectious diseases, neurodegenerative disorders, and cancer. Moreover, regarding cancer immunotherapy, RNAi therapeutics showed potential immunomodulatory ability by downregulating suppressive receptors such as PD-1 and CTLA-4, which restrict immune cell function and present challenges in cancer immunotherapy. Therefore, compared with extracellular targeting by antibodies, RNAi-mediated, cell-intrinsic disruption of inhibitory pathways in immune cells can promote an increased antitumor immune response. Along with nonviral vectors, DNA-based RNAi strategies might be a more promising method for immunomodulation to silence multiple inhibitory pathways in T cells than immune checkpoint blockade antibodies. Thus, in this review, we discuss diverse RNAi implementation strategies, with recent viral and non-viral mediated RNAi synergism to immunotherapy that augments the antitumor immunity. Finally, we provide the current progress of RNAi in clinical pipeline. |
| Databáze: | OpenAIRE |
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