BRAF V600E and risk stratification of thyroid microcarcinoma: a multicenter pathological and clinical study
| Autor: | Domenico Meringolo, Kerry J. Rhoden, Sebastiano Filetti, Gian Piero Casadei, Cosimo Durante, Francesco Nardi, Maria Letizia Bacchi Reggiani, Massimo Torlontano, G. Costante, Michele Bisceglia, Giorgia Acquaviva, Livia Lamartina, Antonella Verrienti, Nadia Cremonini, Dario de Biase, Giuseppe Ronga, Michela Visani, Rocco Bruno, Giovanni Tallini, Annalisa Pession |
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| Přispěvatelé: | Tallini, Giovanni, De Biase, Dario, Durante, Cosimo, Acquaviva, Giorgia, Bisceglia, Michele, Bruno, Rocco, Bacchi Reggiani, Maria Letizia, Casadei, Gian Piero, Costante, Giuseppe, Cremonini, Nadia, Lamartina, Livia, Meringolo, Domenico, Nardi, Francesco, Pession, Annalisa, Rhoden, Kerry J., Ronga, Giuseppe, Torlontano, Massimo, Verrienti, Antonella, Visani, Michela, Filetti, Sebastiano |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Proto-Oncogene Proteins B-raf Pathology medicine.medical_specialty Kaplan-Meier Estimate papillary microcarcinoma Thyroid cancer Pathology and Forensic Medicine microcarcinoma BRAF papillary thyroid carcinoma Risk Factors Fibrosis medicine Carcinoma Humans Thyroid Neoplasms Pathological Retrospective Studies business.industry Surrogate endpoint Thyroid Retrospective cohort study Middle Aged Prognosis medicine.disease Immunohistochemistry Carcinoma Papillary medicine.anatomical_structure Mutation Female business |
| Popis: | Studies from single institutions have analyzed BRAF in papillary microcarcinomas, sometimes with contradictory results. Most of them have provided limited integration of histological and clinical data. To obtain a comprehensive picture of BRAF V600E-mutated microcarcinomas and to evaluate the role of BRAF testing in risk stratification we performed a retrospective multicenter analysis integrating microscopical, pathological, and clinical information. Three hundred and sixty-five samples from 300 patients treated at six medical institutions covering different geographical regions of Italy were analyzed with central review of all cases. BRAF V600E statistical analysis was conducted on 298 microcarcinomas from 264 patients after exclusion of those that did not meet the required criteria. BRAF V600E was identified in 145/298 tumors (49%) including the following subtypes: 35/37 (95%, P |
| Databáze: | OpenAIRE |
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