Virus-induced natural killer cell lysis of T cell subsets
| Autor: | Carey L. O'Donnell, Tara M. Strutt, Catherine H. Castonguay, Keith A. Daniels, Raymond M. Welsh, Susan L. Swain, K. Kai McKinstry |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cytotoxicity Immunologic Male T cell Lymphocyte Mice Transgenic Biology CD8-Positive T-Lymphocytes Lymphocytic Choriomeningitis Lymphocytic choriomeningitis Article Natural killer cell 03 medical and health sciences Mice Interferon T-Lymphocyte Subsets Virology medicine Cytotoxic T cell Animals Lymphocytic choriomeningitis virus 030304 developmental biology Mice Knockout 0303 health sciences 030302 biochemistry & molecular biology medicine.disease Cell biology Killer Cells Natural Mice Inbred C57BL medicine.anatomical_structure biology.protein Receptors Natural Killer Cell Interferons Antibody CD8 medicine.drug |
| Zdroj: | Virology |
| ISSN: | 1096-0341 |
| Popis: | In addition to direct anti-viral activity, NK cells regulate viral pathogenesis by virtue of their cytolytic attack on activated CD4 and CD8 T cells. To gain insight into which differentiated T cell subsets are preferred NK targets, transgenic T cells were differentiated in vitro into Th0, Th1, Th2, Th17, Treg, Tc1, and Tc2 effector cells and then tested for lysis by enriched populations of lymphocytic choriomeningitis virus (LCMV)-induced activated NK cells. There was a distinct hierarchy of cytotoxicity in vitro and in vivo, with Treg, Th17, and Th2 cells being more sensitive and Th0 and Th1 cells more resistant. Some distinctions between in vitro vs in vivo generated T cells were explainable by type 1 interferon induction of class 1 histocompatibility antigens on the effector T cell subsets. NK receptor (NKR)-deficient mice and anti-NKR antibody studies identified no one essential NKR for killing, though there could be redundancies. |
| Databáze: | OpenAIRE |
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