Absence-to-bilateral-tonic-clonic seizure
| Autor: | Sándor Beniczky, Guido Rubboli, Michael R. Sperling, Athanasios Covanis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Pediatrics medicine.medical_specialty Adolescent Clonic seizure Electroencephalography Article Tonic (physiology) Young Adult 03 medical and health sciences 0302 clinical medicine Seizures medicine Humans Ictal Child medicine.diagnostic_test business.industry Generalized seizure Middle Aged 030104 developmental biology Tonic-clonic seizures Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Beniczky, S, Rubboli, G, Covanis, A & Sperling, M R 2020, ' Absence-to-bilateral-tonic-clonic seizure : A generalized seizure type ', Neurology, vol. 95, no. 14, pp. e2009-e2015 . https://doi.org/10.1212/WNL.0000000000010470 Neurology article-version (Version of Record) 3 Beniczky, S, Rubboli, G, Covanis, A & Sperling, M R 2020, ' Absence-to-bilateral-tonic-clonic seizure A generalized seizure type ', Neurology, vol. 95, no. 14, pp. E2009-E2015 . https://doi.org/10.1212/WNL.0000000000010470 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000010470 |
| Popis: | ObjectiveTo test the hypothesis that absence seizures can evolve to generalized tonic-clonic seizures, we documented electroclinical features of this novel seizure type.MethodsIn 4 large video-EEG databases, we identified recordings of seizures starting with impaired awareness that, without returning to baseline interictal state, evolved to generalized tonic-clonic seizures. We extracted the detailed semiologic and electrographic characteristics of these seizures, and we documented the clinical background, diagnoses, and therapeutic responses in these patients.ResultsWe identified 12 seizures from 12 patients. All seizures started with a period of impaired awareness and bursts of generalized spike or polyspike and slow-wave discharges, the hallmark of absence seizures. Without returning to baseline, the nonmotor (absence) phase was followed by tonic-clonic convulsions. We called this novel generalized seizure type absence-to-bilateral-tonic-clonic seizure. Most patients had idiopathic generalized epilepsies, although with a high incidence of unusual features and poor therapeutic response.ConclusionsAbsence-to-bilateral-tonic-clonic seizures are a novel generalized seizure type. Clinicians should be aware of this seizure for correctly diagnosing patients. This novel seizure type may further elucidate generalized ictogenesis. |
| Databáze: | OpenAIRE |
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