Bacterial etiology of bloodstream infections and antimicrobial resistance in Dhaka, Bangladesh, 2005–2014
| Autor: | Abdullah Bashar Sami, Farhana Halim, Sohel Rana, Mahbubur Rahman, Tuhin Sadique, Nasrin Akter, Dilruba Ahmed, Ausrafuggaman Nahid, Shahriar Bin Elahi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Gram-negative bacteria medicine.drug_class Epidemiology Gram-positive bacteria 030106 microbiology Antibiotics Drug resistance Bloodstream infection BSI Salmonella typhi Antimicrobial resistance Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences Medical microbiology Antibiotic resistance Multidrug-resistance (MDR) Medicine Pharmacology (medical) Blood culture lcsh:RC109-216 Bangladesh biology medicine.diagnostic_test business.industry Research Public Health Environmental and Occupational Health biology.organism_classification Infectious Diseases Dhaka business |
| Zdroj: | Antimicrobial Resistance and Infection Control Antimicrobial Resistance and Infection Control, Vol 6, Iss 1, Pp 1-11 (2017) |
| ISSN: | 2047-2994 |
| Popis: | Background Bloodstream infections due to bacterial pathogens are a major cause of morbidity and mortality in Bangladesh and other developing countries. In these countries, most patients are treated empirically based on their clinical symptoms. Therefore, up to date etiological data for major pathogens causing bloodstream infections may play a positive role in better healthcare management. The aim of this study was to identify the bacterial pathogens causing major bloodstream infections in Dhaka, Bangladesh and determine their antibiotic susceptibility pattern. Methods From January 2005 to December 2014, a total of 103,679 single bottle blood samples were collected from both hospitalized and domiciliary patients attending Dhaka hospital, icddrb, Bangladesh All the blood samples were processed for culture using a BACT/Alert blood culture machine. Further identification of bacterial pathogens and their antimicrobial susceptibility test were performed using standard microbiological procedures. Results Overall, 13.6% of the cultured blood samples were positive and Gram-negative (72.1%) bacteria were predominant throughout the study period. Salmonella Typhi was the most frequently isolated organism (36.9% of samples) in this study and a high percentage of those strains were multidrug-resistant (MDR). However, a decreasing trend in the S. Typhi isolation rate was observed and, noticeably, the percentage of MDR S. Typhi isolated declined sharply over the study period. An overall increase in the presence of Gram-positive bacteria was observed, but most significantly we observed the percentage of MDR Gram-positive bacteria to double over the study period. Overall, Gram positive bacteria were more resistant to most of the commonly used antibiotics than Gram-negative bacteria, but the MDR level was high in both groups. Conclusions This study identified the major bacterial pathogens involved with BSI in Dhaka, Bangladesh and also revealed their antibiotic susceptibility patterns. We expect our findings to help healthcare professionals to make informed decisions and provide better care for their patients. Also, we hope this study will assist researchers and policy makers to prioritize their research options to face the future challenges of infectious diseases. Electronic supplementary material The online version of this article (doi:10.1186/s13756-016-0162-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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