Prevalence of SARS-CoV-2 infection in India: Findings from the national serosurvey, May-June 2020

Autor: Swarup Sarkar, Rajkumar Hemalatha, Sanghamitra Pati, Gaurav Raj Dwivedi, Dasarathi Das, P. K. Anand, Avinash Pagdhune, Ashwani Kumar, Y.K. Sharma, Pragya D Yadav, Kiran Rade, S. Muhammad Salim Khan, Inaamul Haq, Alok Kumar Deb, Jyothi Bhat, Balram Bhargava, Sujeet Kumar Singh, C. P. Girish Kumar, Madhuka, G S Toteja, Kanwar Narain, Rakesh Balachandar, Anindya Mitra, Devarajulu Reddy, Kamalesh Sarkar, Marinaik Basavegowdanadoddi Shrinivasa, J P Muliyil, R. Sabarinathan, A.R. Nirmala, Sriram Selvaraju, Chethana Rangaraju, Avula Laxmaiah, Vimith Cheruvathoor Wilson, Naman K. Shah, Prashant Singh, Tekumalla Ramarao, Sanjay Zodpey, Debjit Chakraborty, Gajanan N. Sapkal, Sampada Dipak Bangar, Tarun Bhatnagar, Shripad A. Patil, Smita Asthana, Shashi Kant, Ankit Viramgami, Jeromie Wesley Vivian Thangaraj, Shalini Singh, Hanna Elizabeth Luke, Vijay K. Shukla, Pradeep Das, Amarendra Mahapatra, Manoj V Murhekar, Uma Devi Ranganathan, Alka Turuk, Kangjam Rekha Devi, Samiran Panda, Subash Babu, Muthusamy Santhosh Kumar, Srikanth Tripathy, M. Sunil Kumar, Seema Sahay, Vishal Chopra, V. Saravanakumar, Somashekar Narasimhaiah, Raman R. Gangakhedkar, Shanta Dutta, Giridhara R Babu, Ravindra Mohan Pandey, Rajni Kant, Avi Kumar Bansal, Aparup Das, Krithikaa Sekar, Mariya Amin Qurieshi, Rajiv Yadav
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
lcsh:Medicine
Logistic regression
Antibodies
Viral
0302 clinical medicine
Seroepidemiologic Studies
Pandemic
Medicine
030212 general & internal medicine
Young adult
education.field_of_study
seroprevalence
Incidence (epidemiology)
General Medicine
Middle Aged
serosurveillance
Female
Original Article
ELISA
seroepidemiology
Coronavirus Infections
Adult
medicine.medical_specialty
Adolescent
IgG
030106 microbiology
Population
Pneumonia
Viral
India
Enzyme-Linked Immunosorbent Assay
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Betacoronavirus
Young Adult
Seroprevalence
Humans
education
Pandemics
antibody - covid-19 - elisa - igg - india - sars-cov-2 - seroepidemiology - seroprevalence - serosurveillance
Antibody
Aged
business.industry
SARS-CoV-2
Public health
lcsh:R
COVID-19
Confidence interval
Immunoglobulin G
business
Demography
Zdroj: The Indian Journal of Medical Research
Indian Journal of Medical Research, Vol 152, Iss 1, Pp 48-60 (2020)
ISSN: 0971-5916
Popis: Background & objectives: Population-based seroepidemiological studies measure the extent of SARS-CoV-2 infection in a country. We report the findings of the first round of a national serosurvey, conducted to estimate the seroprevalence of SARS-CoV-2 infection among adult population of India. Methods: From May 11 to June 4, 2020, a randomly sampled, community-based survey was conducted in 700 villages/wards, selected from the 70 districts of the 21 States of India, categorized into four strata based on the incidence of reported COVID-19 cases. Four hundred adults per district were enrolled from 10 clusters with one adult per household. Serum samples were tested for IgG antibodies using COVID Kavach ELISA kit. All positive serum samples were re-tested using Euroimmun SARS-CoV-2 ELISA. Adjusting for survey design and serial test performance, weighted seroprevalence, number of infections, infection to case ratio (ICR) and infection fatality ratio (IFR) were calculated. Logistic regression was used to determine the factors associated with IgG positivity. Results: Total of 30,283 households were visited and 28,000 individuals were enrolled. Population-weighted seroprevalence after adjusting for test performance was 0.73 per cent [95% confidence interval (CI): 0.34-1.13]. Males, living in urban slums and occupation with high risk of exposure to potentially infected persons were associated with seropositivity. A cumulative 6,468,388 adult infections (95% CI: 3,829,029-11,199,423) were estimated in India by the early May. The overall ICR was between 81.6 (95% CI: 48.3-141.4) and 130.1 (95% CI: 77.0-225.2) with May 11 and May 3, 2020 as plausible reference points for reported cases. The IFR in the surveyed districts from high stratum, where death reporting was more robust, was 11.72 (95% CI: 7.21-19.19) to 15.04 (9.26-24.62) per 10,000 adults, using May 24 and June 1, 2020 as plausible reference points for reported deaths. Interpretation & conclusions: Seroprevalence of SARS-CoV-2 was low among the adult population in India around the beginning of May 2020. Further national and local serosurveys are recommended to better inform the public health strategy for containment and mitigation of the epidemic in various parts of the country.
Databáze: OpenAIRE
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