β-Hydroxy-α-ketobutyric acid in Drosophila melanogaster, with reference to biosynthesis of drosopterins
| Autor: | Miki Akino, Masahiro Masada |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Eye Color
Pteridines Pterin metabolism fungi Mutant Biophysics Hydroxybutyrates Biology biology.organism_classification Biochemistry Pterins chemistry.chemical_compound Drosophila melanogaster Column chromatography Biosynthesis chemistry Mutation Animals Reactivity (chemistry) Molecular Biology Drosophila |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 630:92-102 |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/0304-4165(80)90140-3 |
| Popis: | A substance designated as compound D, which reacts spontaneously with 7,8-dihydropterin to give drosopterins, is found in Drosophila melanogaster. The compound was partially purified from the extract of flies by column chromatography and identified as beta-hydroxy-alpha-ketobutyric acid by analysis of its 2,4-dinitrophenylhydrazone, mass spectrometry and reactivity with 7,8-dihydropterin. A highly significant correlation (r=0.969, p less than 0.001) was found between the amounts of the compound and drosopterins in the eye-pigment mutants of Drosophila. Changes of the compound during development of flies were also closely related to those of drosopterins. Based on these observations, a role of the compound in biosynthesis of drosopterins has been discussed. |
| Databáze: | OpenAIRE |
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