Microbiota–host communications: Bacterial extracellular vesicles as a common language
| Autor: | Rogers Alberto Nahui Palomino, Christophe Vanpouille, Leonid Margolis, Paolo E. Costantini |
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| Přispěvatelé: | Ñahui Palomino, Rogers A, Vanpouille, Christophe, Costantini, Paolo E, Margolis, Leonid |
| Rok vydání: | 2021 |
| Předmět: |
Gram-negative bacteria
QH301-705.5 Bioactive molecules Immunology Review Pathology and Laboratory Medicine Microbiology Extracellular vesicles Extracellular Vesicles Microbial Control Virology Gut bacteria Medicine and Health Sciences Genetics Animals Humans Vesicles Biology (General) Gram Negative Bacteria Microbial Pathogens Molecular Biology Pharmacology Bacteria Host Microbial Interactions biology Gram Positive Bacteria Gut Bacteria Host Cells Organisms Biology and Life Sciences Bacteriology Microbiota Host Bacteria Extracellular vesicles Cell Biology Mother cells RC581-607 biology.organism_classification Bacterial Pathogens Cell biology Medical Microbiology Antibiotic Resistance Parasitology Antimicrobial Resistance Pathogens Cellular Structures and Organelles Immunologic diseases. Allergy Viral Transmission and Infection Biogenesis |
| Zdroj: | PLoS Pathogens, Vol 17, Iss 5, p e1009508 (2021) PLoS Pathogens |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1009508 |
| Popis: | Both gram-negative and gram-positive bacteria release extracellular vesicles (EVs) that contain components from their mother cells. Bacterial EVs are similar in size to mammalian-derived EVs and are thought to mediate bacteria–host communications by transporting diverse bioactive molecules including proteins, nucleic acids, lipids, and metabolites. Bacterial EVs have been implicated in bacteria–bacteria and bacteria–host interactions, promoting health or causing various pathologies. Although the science of bacterial EVs is less developed than that of eukaryotic EVs, the number of studies on bacterial EVs is continuously increasing. This review highlights the current state of knowledge in the rapidly evolving field of bacterial EV science, focusing on their discovery, isolation, biogenesis, and more specifically on their role in microbiota–host communications. Knowledge of these mechanisms may be translated into new therapeutics and diagnostics based on bacterial EVs. |
| Databáze: | OpenAIRE |
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