mRNA/lncRNA expression patterns and the function of fibrinogen‐like protein 2 in Meishan pig endometrium during the preimplantation phases
| Autor: | Yueying Wang, Minggang Lei, Lihang Wu, Tingting Kang, Renwu Hua, Wenchao Li, Songyi Xue |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Swine Biology Endometrium 03 medical and health sciences 0302 clinical medicine Pregnancy Gene expression Genetics medicine Animals Conceptus Embryo Implantation RNA Messenger Gene Messenger RNA 030219 obstetrics & reproductive medicine Fibrinogen Gene Expression Regulation Developmental RNA Embryo Meishan pig Cell Biology biology.organism_classification Cell biology 030104 developmental biology medicine.anatomical_structure Female RNA Long Noncoding Developmental Biology |
| Zdroj: | Molecular Reproduction and Development. 86:354-369 |
| ISSN: | 1098-2795 1040-452X |
| Popis: | Embryonic implantation involves a complex and well-coordinated interaction between the developing conceptus and maternal uterus, and the preimplantation period has a major impact on litter size in pigs. The present study aimed to investigate the vital messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) that regulate preimplantation in Meishan pigs. The enriched Gene Ontology terms were all related to "binding." Furthermore, "ECM-receptor interaction" was predicted as an important pathway that regulated the success of implantation. We speculated that the differentially expressed mRNAs S100A9, ANXA8, MUC16, and FGL2 and the differentially expressed lncRNAs TCONS_11206566, TCONS_09904861, and TCONS_1252933 may play vital roles in the process of implantation. Furthermore, this study verified that FGL2 was highly expressed on Day 12 of pregnancy, and we also investigated the function of FGL2 during preimplantation in vivo. In conclusion, this study provides useful information for further analyses of the molecular mechanisms of implantation in Chinese domestic pigs. |
| Databáze: | OpenAIRE |
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