Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative

Autor:	Hideo Sato, Kentaro Kogure, Tatsuya Fukuta, Atsushi Nakayama, Tabassum Ara, Tenta Nakamura, Kosuke Namba, Sangita Karanjit, Masahiro Abe, Takeshi Harada, Asuka Oda
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Natural product Antioxidant Stereochemistry Dimer medicine.medical_treatment Organic Chemistry Dihydroisocoumarin Biochemistry chemistry.chemical_compound chemistry Drug Discovery Edaravone medicine Cytotoxicity Derivative (chemistry) Biaryl dimer
Zdroj:	Tetrahedron Letters. 74:153176
ISSN:	0040-4039
Popis:	A biaryl dimer based on eurotiumide A, a dihydroisocoumarin-type natural product possessing a 1,4-hydroquinone skeleton, was synthesized herein. The radical scavenging activity and cytotoxicity were evaluated. The prepared biaryl dimer and eurotiumide A displayed comparable potent antioxidant activities to those of α-tocopherol and edaravone. However, the biaryl dimer did not show any cytotoxicity against murine colon and human myeloma cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00cf1dfad023898846b4485edb45c44 http://repo.lib.tokushima-u.ac.jp/116179 Zobrazit plný text záznamu Full Text from ScienceDirect