Natriuretic effect of barnidipine, a long-acting dihydropyridine calcium channel blocker, in patients with essential hypertension
| Autor: | Ohta Y, Yusuke Ohya, Fujii K, Fujishima-Nakao Y, Abe I, Onaka U, Kagiyama S, Fujishima M |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Barnidipine Nifedipine Urinary system Natriuresis Diuresis Essential hypertension Excretion chemistry.chemical_compound Atrial natriuretic peptide Internal medicine medicine Humans Single-Blind Method Pharmacology (medical) Aged Pharmacology Aldosterone Middle Aged Calcium Channel Blockers medicine.disease Blood pressure Endocrinology chemistry Hypertension Female medicine.drug |
| Zdroj: | Int. Journal of Clinical Pharmacology and Therapeutics. 38:304-308 |
| ISSN: | 0946-1965 |
| DOI: | 10.5414/cpp38304 |
| Popis: | OBJECTIVE To evaluate the effect of barnidipine hydrochloride, a long-acting dihydropyridine calcium channel blocker on urinary sodium excretion in patients with essential hypertension. PATIENTS Twelve patients (2 males, 10 females) with mild to moderate essential hypertension. METHODS A single-blinded study. After the control (placebo) period, 10 to 15 mg barnidipine hydrochloride was administered for 7 days, followed by a post-treatment (placebo) period. Daily changes in blood pressure, urinary volume, and urinary electrolyte excretions were evaluated. Plasma levels of atrial natriuretic peptide (ANP) and aldosterone were also determined in each period. Daily sodium intake was kept at 120 mEq. RESULTS Blood pressure decreased from 161 +/- 4/92 +/- 2 mmHg to 146 +/- 4/85 +/- 2 mmHg (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|