The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury
| Autor: | Jonathan P. Coles, Ari Katila, Joanne G. Outtrim, Mark van Gils, Jussi Tallus, Hilkka Runtti, M. Iftakher Hossain, Olli Tenovuo, Henna-Riikka Maanpää, Janek Frantzén, Anna Kyllönen, Henna Ala-Seppälä, Riikka S.K. Takala, David K. Menon, Peter J. Hutchinson, Jussi P. Posti, Virginia F. J. Newcombe |
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| Přispěvatelé: | Newcombe, Virginia [0000-0001-6044-9035], Outtrim, Joanne [0000-0001-8118-6430], Coles, Jonathan [0000-0003-4013-679X], Hutchinson, Peter [0000-0002-2796-1835], Menon, David [0000-0002-3228-9692], Apollo - University of Cambridge Repository |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Traumatic brain injury Severity 03 medical and health sciences 0302 clinical medicine UCH-L1 Brain Injuries Traumatic Glial Fibrillary Acidic Protein medicine Humans Glasgow Coma Scale Prospective Studies Prospective cohort study Pathological Aged ta3126 Glial fibrillary acidic protein biology GFAP business.industry traumatic brain injury Area under the curve 030208 emergency & critical care medicine Middle Aged Prognosis medicine.disease ta3124 Confidence interval ROC Curve nervous system biology.protein biomarker Biomarker (medicine) Female Surgery Neurology (clinical) business Ubiquitin Thiolesterase Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Posti, J, Takala, R S K, Runtti, H, Newcombe, V F, Outtrim, J, Katila, A J, Frantzén, J, Ala-Seppälä, H, Coles, J P, Hossain, M I, Kyllönen, A, Maanpää, H-R, Tallus, J, Hutchinson, P J, van Gils, M, Menon, D K & Tenovuo, O 2016, ' The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings ', Neurosurgery, vol. 79, no. 3, pp. 456-464 . https://doi.org/10.1227/NEU.0000000000001226 |
| ISSN: | 0148-396X |
| DOI: | 10.1227/neu.0000000000001226 |
| Popis: | BACKGROUND: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI). OBJECTIVE: We investigated the relation of the GFAP and UCH-L1 levels to the severity of TBI during the first week after injury. METHODS: Plasma UCH-L1 and GFAP were measured from 324 consecutive patients with acute TBI and 81 control subject enrolled in a 2-center prospective study. The baseline measures included initial Glasgow Coma Scale (GCS), head computed tomographic (CT) scan at admission, and blood samples for protein biomarkers that were collected at admission and on days 1, 2, 3, and 7 after injury. RESULTS: Plasma levels of GFAP and UCH-L1 during the first 2 days after the injury strongly correlated with the initial severity of TBI as assessed with GCS. Additionally, levels of UCH-L1 on the seventh day after the injury were significantly related to the admission GCS scores. At admission, both biomarkers were capable of distinguishing mass lesions from diffuse injuries in CT, and the area under the curve of the receiver-operating characteristic curve for prediction of any pathological finding in CT was 0.739 (95% confidence interval, 0.636-0.815) and 0.621 (95% confidence interval, 0.517-0.713) for GFAP and UCH-L1, respectively. CONCLUSION: These results support the prior findings of the potential role of GFAP and UCH-L1 in acute-phase diagnostics of TBI. The novel finding is that levels of GFAP and UCH-L1 correlated with the initial severity of TBI during the first 2 days after the injury, thus enabling a window for TBI diagnostics with latency. ABBREVIATIONS: AUC, area under the curveCI, confidence intervalED, emergency departmentGCS, Glasgow Coma ScaleGRAP, glial fibrillary acidic proteinIMPACT, International Mission for Prognosis and Clinical TrialROC, receiver-operating characteristicTBI, traumatic brain injuryTRACK-TBI, Transforming Research and Clinical Knowledge in Traumatic Brain InjuryUCH-L1, ubiquitin C-terminal hydrolase-L1. |
| Databáze: | OpenAIRE |
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