Analgesic efficacy of celecoxib in patients after oral surgery: special reference to time to onset of analgesia and duration of analgesic effect

Autor: Mitsunobu Otsuru, Yoshihide Ota, Takayuki Aoki, Akihiro Kaneko, Mikio Ota, Yusuke Mori
Rok vydání: 2016
Předmět:
Zdroj: Oral and Maxillofacial Surgery. 20:265-271
ISSN: 1865-1569
1865-1550
DOI: 10.1007/s10006-016-0565-2
Popis: Cyclooxygenase-2 inhibitor celecoxib is also used in the dental field for analgesia. However, there are few reports on the time to onset and duration of analgesia. We investigated the analgesic effect of celecoxib after oral surgery.A total of 138 patients undergoing unilateral mandibular third molar surgery under local anesthesia were enrolled. After surgery, the patients who felt pain and requested an analgesic were instructed to take celecoxib 400 mg and to record the time. Primary efficacy outcome measures were time to onset of analgesia. In addition, the conditions of pain at the time of taking celecoxib, at the onset time of analgesia, and 2 and 6 h after taking the drug were recorded. Pain assessments were evaluated using a 10-cm visual analog scale and four-point verbal rating score. These data were documented in the questionnaire forms handed to the patients and retrieved by post.Effective responses without missing were returned from 103 patients. The median time to onset of the efficacy was 35 min. The pain scales at celecoxib administration was significantly higher compared with the time of onset of analgesia, 2 hours after administraton and 6 hours hours administration (P0.05, respectively). The pain scales at the onset time of analgesia were significantly higher compared to that after 2 or 6 h of taking the drug (P0.05, respectively). There were no statistically significant differences in the pain scales between 2 and 6 h after taking the drug (P0.05).The analgesic effect of celecoxib was exhibited quickly and sustained after oral surgery.
Databáze: OpenAIRE
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