Myeloid cell responses after spinal cord injury
| Autor: | David, S., Kroner, A., Greenhalgh, A.D., Zarruk, J.G., López Vales, Rubén, Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia |
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| Přispěvatelé: | McGill University = Université McGill [Montréal, Canada], Medical College of Wisconsin, Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Universitat Autònoma de Barcelona (UAB) |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell physiology Myeloid Neutrophils [SDV]Life Sciences [q-bio] Immunology Cell Biology Monocytes Transcriptome 03 medical and health sciences 0302 clinical medicine Immunity medicine Animals Humans Immunology and Allergy Myeloid Cells Spinal cord injury Spinal Cord Injuries Immunity Cellular [SDV.GEN]Life Sciences [q-bio]/Genetics Microglia Macrophages medicine.disease Phenotype 3. Good health [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics 030104 developmental biology medicine.anatomical_structure Neurology Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Journal of Neuroimmunology Journal of Neuroimmunology, Elsevier, 2018, 321, pp.97-108. ⟨10.1016/j.jneuroim.2018.06.003⟩ Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2018.06.003⟩ |
| Popis: | The work done in the authors labs were supported by grants from the Canadian Institutes of Health Research (MOP-14828 and MOP-142231), and the MS Society of Canada (#2112) (SD); Wings for Life Spinal Cord Research Foundation (WFL-US-13/16), and Advancing a Healthier Wisconsin Endowment (5520363) (AK); and the Spanish Ministry of Economy and Competiiveness (SAF2016-79774-R), International Foundation for Research in Paraplegia (P148), Wings for Life Spinal Cord Research Foundation (WFL-ES-14/17) and by funds from the Fondo de Investigación Sanitaria of Spain (TERCEL and CIBERNED) (RLV). We also wish to thank our many collaborators. The past decade has revealed much about the complexity of the local inflammatory response after spinal cord injury (SCI). A major challenge is to distinguish between microglia and monocyte-derived macrophages (MDMs) to determine their phenotype and function. Transcriptome studies have revealed microglia-selective genes but are still limited in scope because many markers are downregulated after injury. Additionally, new genetic reporter mice are available to study microglia and MDMs. There is more evidence now for the plasticity and heterogeneity of microglia and MDMs. We also discuss the role of neutrophils that are the first peripheral cells to enter the injured CNS. Altres ajuts: International Foundation for Research in Paraplegia: WFL-ES-14/17, P148; Wings for Life: WFL-US-13/16; Advancing a Healthier Wisconsin Endowment: 5520363; MS Society of Canada: 2112; Canadian Institutes of Health Research:MOP-14828, MOP-142231 |
| Databáze: | OpenAIRE |
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