Insulin-like growth factor I and risk of incident cancer in elderly men - results from MrOS (Osteoporotic Fractures in Men) in Sweden
| Autor: | Jan-Erik Damber, Daniel Carlzon, Östen Ljunggren, Johan Svensson, Magnus Karlsson, Dan Mellström, Max Petzold, Mohammad-Ali Haghsheno, Claes Ohlsson |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Bioinformatics Risk Assessment Cohort Studies 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Endocrinology Risk Factors Internal medicine Neoplasms Surveys and Questionnaires Epidemiology Medicine Humans Registries Insulin-Like Growth Factor I Aged Proportional Hazards Models Cancer mortality Aged 80 and over Sweden business.industry Incidence Cancer Prostatic Neoplasms medicine.disease 030104 developmental biology Cancer incidence 030220 oncology & carcinogenesis business Cancer risk Osteoporotic Fractures |
| Zdroj: | Clinical endocrinology. 84(5) |
| ISSN: | 1365-2265 |
| Popis: | Studies of the association between circulating IGF-I and cancer risk have shown conflicting results. We have previously observed a U-shaped association between IGF-I and cancer mortality. This study test the hypotheses of a U-shaped association between IGF-I and incident cancer.Elderly men (2368), randomly recruited from the general community.IGF-I was measured in a cohort of elderly men. Complete data for incident cancer were obtained from the Swedish Cancer Registry. Statistical analyses included Cox proportional hazards regressions with or without a spline approach.Three hundred and sixty-nine participants had incident cancer after baseline. Prostate cancer was most frequent (n = 140). There was no association between serum IGF-I and all cancer or prostate cancer incidence. However, there was a nonlinear association between IGF-I and nonprostate cancer incidence (P =0·05). Exploratory analyses were performed for low and high serum IGF-I (quintiles 1 and 5) vs intermediate (quintiles 2-4, referent). There was a tendency of increased nonprostate cancer risk in men with high IGF-I (HR = 1·26, 95% confidence interval (CI): 0·92-1·71, P = 0·15). After excluding participants with follow-up of less than 2·6 years (half median follow-up time), to control for potential diagnostic delay, the association was statistically significant (HR = 1·55, CI: 1·03-2·35).There was a significant nonlinear association between IGF-I and nonprostate cancer. No association between IGF-I and prostate cancer was observed. Future studies are warranted to further investigate this nonlinear association, including whether IGF-I concentration is a reproducible, and useful, risk marker of nonprostate cancer. |
| Databáze: | OpenAIRE |
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