Clinical application of carbon nanoparticles in lymphatic mapping during colorectal cancer surgeries: A systematic review and meta-analysis
| Autor: | Xiaoling Deng, Jiahuan Li, Li-Yu Wang, Jing-Song Liu, Keshu Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer law.invention 03 medical and health sciences Intraoperative Period 0302 clinical medicine Randomized controlled trial law Internal medicine Medicine Humans Randomized Controlled Trials as Topic Hepatology business.industry Nanotubes Carbon Gastroenterology medicine.disease Confidence interval Dissection Lymphatic system Data extraction Sample size determination 030220 oncology & carcinogenesis Meta-analysis Lymphatic Metastasis Lymph Node Excision Nanoparticles 030211 gastroenterology & hepatology Lymph Nodes business Colorectal Neoplasms |
| Zdroj: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 52(12) |
| ISSN: | 1878-3562 |
| Popis: | To investigate the overall performance of carbon nanoparticles (CNs) for detecting lymph nodes (LNs) and node metastasis during colorectal cancer surgery.The English and Chinese literature was searched until 29 April 2020. Studies were included if they were randomized controlled trials (RCTs) for colorectal resection and LN dissection that compared the use of CNs with a blank control in colorectal cancer surgery. Quality assessment and data extraction were performed, and a meta-analysis was conducted using ReviewManager 5.3 and Stata 15.1 software.A total of 17 RCTs comprising 1241 patients were included for analysis. Compared with the outcomes of the blank controls, the use of CNs resulted in an average of 5.21 more LNs per patient (weighted mean difference = 5.21, 95% confidence interval [CI] = 4.14-6.29, p0.001) and a 68% higher detection rate of micro LNs (relative risk [RR] = 1.68, 95% CI = 1.38-2.04, p0.001). In addition, more metastatic LNs were identified in stained nodes (RR = 1.56, 95% CI = 1.40-1.75, p0.001), but the total detection rate of metastatic nodes did not differ between the groups.CN is an effective lymphatic tracer in colorectal cancer surgeries. Further studies with larger sample sizes are needed to validate these findings. |
| Databáze: | OpenAIRE |
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