Superior sagittal sinus thrombosis due to lithium: Local urokinase thrombolysis treatment
| Autor: | M Wasay, George Bobustuc, Suleman Kojan, Neeraj Dubey, Rohit Bakshi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Bipolar Disorder Lithium (medication) Lithium Plasminogen Activators Antimanic Agents medicine Humans Sagittal Sinus Thrombosis Papilledema Urokinase business.industry Nephrogenic diabetes insipidus medicine.disease Urokinase-Type Plasminogen Activator Thrombosis Surgery Venous thrombosis Diabetes insipidus Female Neurology (clinical) medicine.symptom Tomography X-Ray Computed business medicine.drug Superior sagittal sinus |
| Zdroj: | Neurology. 54:532-532 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.54.2.532 |
| Popis: | Superior sagittal sinus thrombosis (SSST) is associated with a host of predisposing factors, including pregnancy, collagen vascular disease, malignancy, diabetes insipidus, and medications such as oral contraceptive agents, l-asparaginase, androgens, and heparin.1 The diagnosis of cerebral venous thrombosis may be challenging,2 so it is important to recognize underlying causes. We report a young woman with SSST associated with lithium-induced nephrogenic diabetes insipidus. This is the first reported case of venous sinus thrombosis secondary to lithium therapy. The patient was treated successfully with local urokinase thrombolysis. A 30-year-old woman with a history of bipolar disorder presented with progressive headache, confusion, visual blurring, and left hemiparesis. She had been taking lithium, risperidone, and oral contraceptive agents for many years. Neurologic examination showed confusion, papilledema, and mild left hemiparesis. Urine output was markedly elevated (greater than 200 mL/hour). Significant laboratory abnormalities included serum platelet count 106,000/mm3, sodium … |
| Databáze: | OpenAIRE |
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