Involvement of renal nerves and endothelins in the regulation of renal water excretion in diabetes insipidus rats
| Autor: | Natcho Nattcheff, Petia Markova, Dimitar Mikhov, Tatiana Avramova, Radoslav Girchev |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.hormone
Male medicine.medical_specialty Vasopressin Blood Pressure urologic and male genital diseases Kidney Endothelins chemistry.chemical_compound Heart Rate Internal medicine medicine Animals Receptor BQ-123 business.industry Osmolar Concentration Water General Medicine Water excretion medicine.disease Denervation Rats Endocrinology chemistry Nephrology Excretory system Diabetes insipidus cardiovascular system Cardiology and Cardiovascular Medicine business Diabetes Insipidus |
| Zdroj: | Kidneyblood pressure research. 24(1) |
| ISSN: | 1420-4096 |
| Popis: | The interaction between renal nerves, endothelins acting via endothelin-A receptors and vasopressin in the regulation of renal excretory function was investigated. In conscious intact and renal denervated diabetes insipidus (DI) Brattleboro rats, as well as their controls, Long-Evans (LE) rats, an infusion of 16.4 nmol/kg/min ETA receptor antagonist BQ-123 was performed in the course of 50 min. Femoral artery blood pressure, heart rate, Ccr, V · UNa, V · UK and V · UCl did not alter in any of the groups. Urine flow rate diminished by 38.1% (p < 0.02), while urine osmolality increased by 30.3% (p < 0.05) as a result of BQ-123 infusion in the intact LE rats but neither urine flow rate nor urine osmolality changed in the DI rats. In contrast to intact LE rats, BQ-123 infusion in renal denervated LE rats did not alter urine flow rate or urine osmolality. However, urine flow rate in renal denervated DI rats surprisingly decreased by 71.1% (p < 0.01) while urine osmolality increased by 161% (p < 0.001) as a result of BQ-123 infusion. Endogenous endothelins can regulate renal water excretion through ETA receptor activation. Renal sympathetic nerves participate in the modulation of renal water excretion influencing the ETA receptor-mediated effects of endothelins in the kidney. |
| Databáze: | OpenAIRE |
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