Reductions of myocardial Na-K-ATPase activity and ouabain binding sites in heart failure: prevention by nadolol
| Autor: | Tai-Hwang M. Fan, R. P. Frantz, H. Elam, Chang-seng Liang, S. Sakamoto, N. Imai |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Physiology Hemodynamics Strophanthidin Digitalis Dogs Nadolol Isometric Contraction Physiology (medical) Internal medicine medicine.artery medicine Carnivora Animals Na+/K+-ATPase Ouabain Heart Failure Binding Sites biology business.industry Myocardium Fissipedia biology.organism_classification medicine.disease Myocardial Contraction Endocrinology Heart failure Pulmonary artery Ventricular Function Right Sodium-Potassium-Exchanging ATPase Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 265:H2086-H2093 |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | To study the changes in myocardial digitalis binding sites in heart failure, we measured myocardial ouabain binding sites, Na-K-adenosinetriphosphatase (ATPase) activity, and ventricular muscle mechanical responses to acetylstrophanthidin in dogs with right-heart failure (RHF) produced by tricuspid avulsion and pulmonary artery constriction. Sham-operated dogs were studied as the control. RHF produced a significant decrease in ouabain binding sites in the right and left ventricular myocardium, which was accompanied by a proportional decrease in Na-K-ATPase activity. However, RHF and sham-operated dogs did not differ in systemic hemodynamic or right ventricular trabeculate muscle isometric contractile responses to acetylstrophanthidin. To determine whether chronic beta-adrenergic stimulation contributed to the development of Na-K-ATPase downregulation, we administered nadolol (40 mg/day) to a separate group of dogs during an early stage of RHF development. Nadolol effectively prevented the reduction of myocardial ouabain binding sites that occurred in RHF. Thus we conclude that myocardial ouabain binding sites and Na-K-ATPase activity are reduced in dogs with experimental heart failure and that these changes probably occur as a result of the attendant heightened sympathetic activity. |
| Databáze: | OpenAIRE |
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