Anti-apolipoprotein A-1 autoantibodies correlate with disease activity in systemic lupus erythematosus
| Autor: | Nicolas Vuilleumier, Pascale Roux-Lombard, Montserrat Alvarez, Delphine S. Courvoisier, Haïg Nigolian, Uyen Huynh-Do, Carlo Chizzolini, Sabrina Pagano, Jean-Michel Dayer, Camillo Ribi, Marten Trendelenburg |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Apolipoprotein B Adolescent 610 Medicine & health Severity of Illness Index Immunoglobulin G 03 medical and health sciences Young Adult 0302 clinical medicine Rheumatology Prednisone Medicine Humans Lupus Erythematosus Systemic Pharmacology (medical) Child Apolipoproteins A Aged Autoantibodies 030203 arthritis & rheumatology ddc:616 biology business.industry Anti-dsDNA antibodies Reverse cholesterol transport Autoantibody Middle Aged 030104 developmental biology Immunology biology.protein Biomarker (medicine) lipids (amino acids peptides and proteins) Female Antibody business medicine.drug |
| Zdroj: | Rheumatology (2019) Nigolian, Haïg; Ribi, Camillo; Courvoisier, Delphine S; Pagano, Sabrina; Alvarez, Montserrat; Trendelenburg, Marten; Huynh-Do, Uyen; Vuilleumier, Nicolas; Dayer, Jean-Michel; Chizzolini, Carlo; Roux-Lombard, Pascale (2020). Anti-apolipoprotein A-1 autoantibodies correlate with disease activity in systemic lupus erythematosus. Rheumatology, 59(3), pp. 534-544. Oxford University Press 10.1093/rheumatology/kez306 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/kez306 |
| Popis: | Objectives Apolipoprotein A-1 (ApoA-1) is a protein fraction of the high-density lipoproteins with anti-inflammatory and antioxidant properties that play a major role in reverse cholesterol transport. The presence of anti-ApoA-1 IgG has been reported in SLE to be variably associated with disease activity or cardiovascular events (CVEs). We assessed the clinical performance of anti-ApoA-1 IgG and of antibodies directed against its immunodominant F3L1 peptide (F3L1 IgG) in a well-characterized Swiss SLE cohort study. Methods A total of 354 biological samples and interviews from 176 individuals were studied. SLEDAI, clinical characteristics, anamnestic CVEs and therapy details were recorded. Sera were tested for the presence of anti-ApoA-1 IgG, anti-F3L1 IgG, anti-dsDNA IgG and aPL. Results Anti-ApoA-1 and anti-F3L1 IgG positivity was associated with higher SLEDAI, mostly due to concomitant positivity of dsDNA IgG and low complement. Variations in time of anti-ApoA-1 IgG correlated positively with variations of anti-dsDNA IgG and inversely to variations of C3 levels. No cross-reactivity was found between anti-ApoA-1 and anti-dsDNA IgG. Positivity for anti-Apo-A1 IgG was more frequent in individuals receiving 10 mg/day or more of prednisone. We did not find any significant association between anti-ApoA-1 IgG positivity and CVEs. Conclusion Anti-ApoA-1 and anti-F3L1 IgG in SLE correlate strongly with laboratory markers of activity, particularly with the presence and titre of dsDNA IgG. These results confirm and extend previous findings and support the use of anti-ApoA1 IgG in the clinical setting. Their role in CVEs deserves further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|