Role of macrophages in host defense against hepatic amoebiasis in hamsters
| Autor: | P. A. L. Kongshavn, E. Meerovitch, E. Ghadirian |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Cytotoxicity
Immunologic Pathology medicine.medical_specialty Immunology Hamster Biology Microbiology Host-Parasite Interactions Entamoeba histolytica Cricetinae parasitic diseases medicine Animals Macrophage Abscess Protozoal disease Axenic Mesocricetus Inoculation Immune Sera Macrophages medicine.disease biology.organism_classification Infectious Diseases Liver Abscess Amebic Hepatic amoebiasis Female Parasitology Rabbits Research Article |
| Zdroj: | Infection and Immunity. 42:1017-1019 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | The role of macrophages in hepatic amoebiasis in hamsters has been investigated by means of antimacrophage serum prepared in rabbits. Animals treated with normal rabbit serum or antimacrophage serum, as well as untreated controls, were inoculated intrahepatically with 10(5) axenic trophozoites of Entamoeba histolytica. In hamsters treated with antimacrophage serum before intrahepatic inoculation of amoebae, the mean weight of the metastatic foci was significantly greater than in normal rabbit serum-treated or untreated controls. Treatment of hamsters with antimacrophage serum both before and after administration of amoebae not only increased significantly the size of the abscess in the liver but also allowed dissemination of metastatic foci to other organs. |
| Databáze: | OpenAIRE |
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