Fatal case of cryptogenic organizing pneumonia associated with Everolimus
| Autor: | Nour Alfaqeer, Samer Salah, Jakub Khzouz, Lama Nazer, Taghreed Al-Najjar, Monther Qandeel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics lcsh:Medicine law.invention Granulomatous inflammation Fatal Outcome law Internal medicine medicine Carcinoma Humans Everolimus Carcinoma Renal Cell Pneumonitis Sirolimus medicine.diagnostic_test business.industry lcsh:R General Medicine Middle Aged medicine.disease Intensive care unit Kidney Neoplasms Radiography Cryptogenic Organizing Pneumonia Chest radiograph business Immunosuppressive Agents medicine.drug |
| Zdroj: | Annals of Saudi Medicine, Vol 34, Iss 5, Pp 437-439 (2014) |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.2014.437 |
| Popis: | Noninfectious pneumonitis (NIP) has been reported with everolimus; however, the majority of the reported cases were mild to moderate. We report a fatal case of cryptogenic organizing pneumonia (COP) in a 61-year-old man. About 4 weeks after starting everolimus, the patient was admitted to the hospital with complaints of a 1-week history of progressive dyspnea with exertion and cough. The chest radiograph showed bilateral multifocal dense opacities, and he was started on antibiotics. However, his respiratory status deteriorated, and he was subsequently intubated and transferred to the intensive care unit. Chest computed tomography showed bronchocentric consolidation associated with widespread bilateral fine reticular opacification. Video-assisted thoracoscopic lung biopsy showed noncaseating granulomatous inflammation and features of COP. All cultures were negative for bacterial, viral, and fungal infections. Despite discontinuing everolimus and initiating corticosteroids, the patient died of progressive respiratory failure secondary to COP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|