Roscovitine inhibits ongoing DNA synthesis in human cervical cancer

Autor:	Héctor Carminatti, Marina Vita, Liliana Vitali, Mabel Cruz, Åke Sidén, Liliana Settembrini, J.Sebastian Yakisich, Alejandro Fernandez, Oscar Casas, Victor Vargas
Rok vydání:	2002
Předmět:	Adult Cancer Research Time Factors Uterine Cervical Neoplasms Purine analogue Antineoplastic Agents Pharmacology Cyclin-dependent kinase Roscovitine medicine Humans Enzyme Inhibitors Protein kinase A Aged chemistry.chemical_classification Dose-Response Relationship Drug DNA synthesis biology Cell growth DNA Middle Aged Cyclin-Dependent Kinases Enzyme Oncology Biochemistry Mechanism of action chemistry Purines Enzyme inhibitor biology.protein Female medicine.symptom
Zdroj:	Cancer Letters. 180:7-12
ISSN:	0304-3835
DOI:	10.1016/s0304-3835(01)00827-8
Popis:	The effect of roscovitine, a purine analogue and cyclin dependent kinase inhibitor, on DNA synthesis rate in tissue mini-units obtained from human cervical cancers was investigated. Roscovitine (100 microM) gave a DNA synthesis rate inhibition by 61% (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf226d1b501019ff9a0f6b888f7c08b0 https://doi.org/10.1016/s0304-3835(01)00827-8 Zobrazit plný text záznamu Full Text from ScienceDirect