The alteration of lymphocyte subsets in idiopathic granulomatous mastitis
| Autor: | Naim Kadoglou, Ayca Emsen, Hande Koksal, Hulya Ucaryilmaz, Hasibe Artac |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Granulomatous mastitis medicine.disease_cause Article Immunophenotyping Autoimmunity medicine Humans Cytotoxic T cell Granulomatous Mastitis Lymphocyte Count Idiopathic granulomatous mastitis lymphocyte subsets business.industry autoimmunity General Medicine Middle Aged Immune dysregulation Flow Cytometry medicine.disease Natural killer T cell Healthy Volunteers Immunoglobulin M Peripheral blood lymphocyte Immunology Female etiopathogenesis business Lymphocyte subsets |
| Zdroj: | Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 |
| DOI: | 10.3906/sag-2012-192 |
| Popis: | Background and aim This study analyzed peripheral blood lymphocyte subsets to determine their role in the etiopathogenesis of IGM. Materials and methods This study includes 51 pathologically proven IGM patients (active disease: 26 and in remission: 25) and 28 healthy volunteers. The analyses of lymphocyte subsets were performed by flow cytometric immunophenotyping. Results The percentage of T helper lymphocyte of all IGM patients were lower than control groups (p = 0.001). Absolute cytotoxic T lymphocyte count (p = 0.03), both percentage (p = 0.035) and absolute count (p = 0.002) of the natural killer cells, and both percentage (p = 0.038) and absolute count (p = 0.008) of natural killer T cells, were higher than the control group. The T helper lymphocyte percentage of the patients with active disease was lower than the control group (p = 0.0003). The absolute cytotoxic T lymphocyte (p = 0.029) and natural killer T cells (p = 0.012) of the patients with active disease were higher than the control group. Conclusion Idiopathic granulomatous mastitis is defined as a localized form of granulomatous disorders. However, the observed changes in T cells, NK, and NKT cells suggest that there is systemic immune dysregulation in patients with IGM. |
| Databáze: | OpenAIRE |
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