Ru(II) Complexes with Diazine Ligands: Electronic Modulation of Coordinating Group is Key to the Design of 'Dual Action' Photoactivated Agents
| Autor: | Sean Parkin, Edith C. Glazer, Dmytro Havrylyuk, Megha S. Deshpande |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Denticity
chemistry.chemical_element Quantum yield 010402 general chemistry 01 natural sciences Catalysis Article Metal chemistry.chemical_compound Materials Chemistry Molecule Diazine 010405 organic chemistry Chemistry Ligand Metals and Alloys Biological activity General Chemistry Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Ruthenium visual_art Ceramics and Composites visual_art.visual_art_medium |
| Popis: | Coordination complexes can be used to photocage biologically active ligands, providing control over the location, time, and dose of a delivered drug. Dual action agents can be created if both the ligand released and the ligand-deficient metal center effect biological processes. Ruthenium (II) complexes coordinated to pyridyl ligands generally are only capable of releasing one ligand in H(2)O, wasting equivalents of drug molecules, and producing a Ru(II) center that is not cytotoxic. In contrast, Ru(II) polypyridyl complexes containing diazine ligands eject both monodentate ligands, with the quantum yield (ϕ(ps)) of the second phase varying as a function of ligand pK(a) and the pH of the medium. This effect is general, as it is effective with different Ru(II) structures, and demonstrates that diazine-based drugs are the preferred choice for the development of light-activated dual action Ru(II) agents. |
| Databáze: | OpenAIRE |
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