A multicenter, randomized, equivalence trial of a new recombinant human chorionic gonadotropin preparation versus ovitrelle® for ovulation in women undergoing intrauterine insemination following ovarian stimulation
| Autor: | Girish P Godbole, Rajan S Vaidya, Ganesh H Divekar, Manish Banker, Y. S. Nandanwar, Manjeet Arora, Gautam Vinod Daftary, Abha Majumdar, Neelu Soni, Rekha Sachan, Rahul V Mayekar, James John |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system media_common.quotation_subject medicine.medical_treatment Context (language use) lcsh:Gynecology and obstetrics Human chorionic gonadotropin 03 medical and health sciences 0302 clinical medicine Medicine recombinant Adverse effect Ovulation lcsh:RG1-991 media_common intrauterine insemination Gynecology Pregnancy 030219 obstetrics & reproductive medicine business.industry medicine.disease Clinical trial 030104 developmental biology Reproductive Medicine Equivalence Trial Ovulation induction ovulation induction business |
| Zdroj: | Journal of Human Reproductive Sciences, Vol 12, Iss 1, Pp 53-58 (2019) |
| ISSN: | 1998-4766 0974-1208 |
| Popis: | Context: A new indigenous recombinant human chorionic gonadotropin (r-hCG) has been developed in India with a comparable pharmacological profile to that of Ovitrelle® (Merck Serono). Aims: This study aims to compare the efficacy and safety of the new r-hCG with that of Ovitrelle for induction of ovulation in women undergoing intrauterine insemination (IUI). Settings and Design: Randomized (2:1), multicenter, open-label, equivalence clinical trial conducted in India. Subjects and Methods: A total of 217 women, aged 20–37 years, undergoing IUI were administered the new r-hCG (test) 250 mcg or Ovitrelle 250 mcg (comparator) after ovarian stimulation with gonadotropins. The ovulation rate was compared as the primary outcome. In addition, pregnancy rates, incidence of adverse events (AEs), and development of immunogenicity were assessed. Statistical Analysis Used: The ovulation and pregnancy rates were compared using Chi-squared test with statistical significance at P < 0.05. Results: With 144 women in the test group and 73 in the comparator group, the ovulation rate (85.4% vs. 78.1%; P = 0.17) and pregnancy rate (serum β hCG test) (11.8% vs. 12.3%; P = 0.91) were similar in both groups. A total of 15 AEs were reported (11 in the test r-hCG group and 4 in the comparator group) in 11 women; none of these were serious, and all were judged to be unrelated to the study drug. No subject developed immunogenic reaction to the test drug. Conclusions: The new preparation of r-hCG was equivalent to the conventional preparation of r-HCG in the induction of ovulation in patients undergoing IUI. |
| Databáze: | OpenAIRE |
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