Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls

Autor: Jacques Morel, Jean Ribstein, R. Audo, Cédric Lukas, Emmanuel Barrat, Gaelle Vial, Claire Daien, Bernard Combe, Sarah Marouen, Anne Tournadre, Guilhem du Cailar
Přispěvatelé: Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de rhumatologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), Université Clermont Auvergne ( UCA ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Physiology
NSAIDs
[SDV]Life Sciences [q-bio]
Arthritis
lcsh:Medicine
Urine
030204 cardiovascular system & hematology
Sodium Chloride
Gastroenterology
Biochemistry
Severity of Illness Index
Arthritis
Rheumatoid
0302 clinical medicine
Rheumatoid
Medicine and Health Sciences
lcsh:Science
2. Zero hunger
Analgesics
Multidisciplinary
Fatty Acids
Drugs
Middle Aged
Lipids
3. Good health
Body Fluids
Chemistry
Antihypertensive Drugs
Rheumatoid arthritis
Physical Sciences
Female
Anatomy
Research Article
medicine.medical_specialty
Sodium
Immunology
Excretion
chemistry.chemical_element
Rheumatoid Arthritis
Autoimmune Diseases
03 medical and health sciences
Rheumatology
Internal medicine
Severity of illness
medicine
Humans
Nutrition
030203 arthritis & rheumatology
Pharmacology
[ SDV ] Life Sciences [q-bio]
business.industry
lcsh:R
Case-control study
Chemical Compounds
Biology and Life Sciences
medicine.disease
Pain management
Diet
Endocrinology
chemistry
Case-Control Studies
Clinical Immunology
Salts
lcsh:Q
Clinical Medicine
business
Physiological Processes
Body mass index
Zdroj: PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0186157. ⟨10.1371/journal.pone.0186157⟩
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0186157. 〈10.1371/journal.pone.0186157〉
PLoS ONE, 2017, 12 (10), pp.e0186157. ⟨10.1371/journal.pone.0186157⟩
PLoS ONE, Vol 12, Iss 10, p e0186157 (2017)
ISSN: 1932-6203
Popis: International audience; OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849\textpm1,350 vs. 2,182\textpm751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028). CONCLUSION: Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.
Databáze: OpenAIRE
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