Cell shape and substrate stiffness drive actin-based cell polarity
| Autor: | Andrew Callan-Jones, Mukund Gupta, Benoit Ladoux, Raphaël Voituriez, Leyla Kocgozlu, René-Marc Mège, Bryant L. Doss, Meng Pan |
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| Přispěvatelé: | Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Jean Perrin (LJP), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physico-Chimie-Curie (PCC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique de la Matière Condensée (LPTMC), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut Curie-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MESH: Biomechanical Phenomena
[SDV]Life Sciences [q-bio] [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] Cell macromolecular substances MESH: Actins Models Biological 01 natural sciences Article 010305 fluids & plasmas MESH: Cell Adhesion Rigidity (electromagnetism) MESH: Mechanical Phenomena 0103 physical sciences Cell polarity Cell Adhesion medicine Substrate stiffness MESH: Cell Shape 010306 general physics Cell shape Cell adhesion Cell Shape ComputingMilieux_MISCELLANEOUS Actin Mechanical Phenomena [PHYS]Physics [physics] Chemistry MESH: Models Biological Cell Polarity Actin cytoskeleton Actins Biomechanical Phenomena medicine.anatomical_structure Biophysics MESH: Cell Polarity |
| Zdroj: | Physical Review E Physical Review E, American Physical Society (APS), 2019, 99 (1), pp.012412. ⟨10.1103/PhysRevE.99.012412⟩ Physical Review E, American Physical Society (APS), 2019, 99 (1), ⟨10.1103/PhysRevE.99.012412⟩ |
| ISSN: | 2470-0045 2470-0053 |
| DOI: | 10.1103/PhysRevE.99.012412⟩ |
| Popis: | International audience; A general trait of living cells is their ability to exert contractile stresses on their surroundings and thus respond to substrate rigidity. At the cellular scale, this response affects cell shape, polarity, and ultimately migration. The regulation of cell shape together with rigidity sensing remains largely unknown. In this article we show that both substrate rigidity and cell shape contribute to drive actin organization and cell polarity. Increasing substrate rigidity affects bulk properties of the actin cytoskeleton by favoring long-lived actin stress fibers with increased nematic interactions, whereas cell shape imposes a local alignment of actin fibers at the cell periphery. |
| Databáze: | OpenAIRE |
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