Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent
| Autor: | Rongli Cui, Binggang Xu, Gengmei Xing, Huan Huang, Huanli Yao, Ying Li, Jinquan Dong, Shuaichao Liu, Cheng Li, Xihong Guo, Bing Liu, Baoyun Sun, Juan Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Contrast enhancement
Materials science Biocompatibility Infrared Rays Contrast Media Mice Nude Uterine Cervical Neoplasms 02 engineering and technology 010402 general chemistry 01 natural sciences Mice Colloid and Surface Chemistry In vivo medicine Animals Humans Physical and Theoretical Chemistry Nir fluorescence Fluorescent Dyes medicine.diagnostic_test Molecular Structure Optical Imaging Magnetic resonance imaging Surfaces and Interfaces General Medicine Neoplasms Experimental 021001 nanoscience & nanotechnology Fluorescence Magnetic Resonance Imaging Imaging agent 0104 chemical sciences Spectrometry Fluorescence Nanoparticles Female Fullerenes 0210 nano-technology Preclinical imaging Biotechnology Biomedical engineering HeLa Cells |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 171 |
| ISSN: | 1873-4367 |
| Popis: | Dual mode imaging technology is widely developed to achieve the early-stage precision cancer diagnosis. Here we designed a dual-modal magnetic resonance/near infrared fluorescence optical imaging contrast agent (GdF-SS-NIR783) with the fluorescence activatable and safer gadofullerene. The nanoprobes were fabricated by conjugating the gadofullerene derivatives with a NIR fluorescence imaging agent (NIR783) via the disulfide bond. The obtained nanoprobes showed no fluorescence (OFF), but the fluorescence turned on when incubated within reduction environment such as GSH solution. The clear fluorescence signal in tumor site was observed obviously after their intratumor injection. The nanoprobes also revealed efficient MRI contrast enhancement both in vitro and in vivo. And they showed good biocompatibility and did not demonstrate any tissue toxicity in vivo. This work gave the new possibility in designing more efficient and safer nanoprobes for future medical diagnoses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect