Effect of synbiotic supplementation on matrix metalloproteinase enzymes, quality of life and dietary intake and weight changes in rectal cancer patients undergoing neoadjuvant chemoradiotherapy
| Autor: | Fatemeh Farshi Radvar, Reza Mahdavi, Mohammad Mohammadzadeh, Behnam Nasirimotlagh, Vibeke Andersen, Elnaz Faramarzi, Neda Lotfi Yagin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer Endocrinology Diabetes and Metabolism synbiotic supplementation Matrix metalloproteinase Gastroenterology 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine Rectal cancer chemistry.chemical_classification Nutrition and Dietetics business.industry Dietary intake medicine.disease Enzyme chemistry quality of life 030220 oncology & carcinogenesis preoperative chemoradiotherapy 030211 gastroenterology & hepatology business dietary intake Food Science Neoadjuvant chemoradiotherapy |
| Zdroj: | Farshi Radvar, F, Mohammad-Zadeh, M, Mahdavi, R, Andersen, V, Nasirimotlagh, B, Faramarzi, E & Lotfi Yagin, N 2020, ' Effect of synbiotic supplementation on matrix metalloproteinase enzymes, quality of life and dietary intake and weight changes in rectal cancer patients undergoing neoadjuvant chemoradiotherapy ', Mediterranean Journal of Nutrition and Metabolism, vol. 13, no. 3, pp. 225-235 . https://doi.org/10.3233/MNM-200413 |
| DOI: | 10.3233/MNM-200413 |
| Popis: | BACKGROUND: Probiotic/synbiotic has the important role of in altering intestinal bacteria, reducing inflammation and improvement of intestinal diseases. OBJECTIVE: We aimed to investigate the effect of synbiotic supplementation on matrix metalloproteinase (MMP) enzymes, hs-CRP, quality of life, dietary intake and weight changes in rectal cancer patients undergoing neoadjuvant chemoradiotherapy (CRT). METHODS: In this study, 46 rectal cancer patients were recruited. Patients were allocated to the synbiotic (n = 23) group or placebo groups (n = 23) receiving 2 synbiotic or placebo capsules for six weeks. Anthropometric measurements, quality of life, dietary intakes, and serum levels of MMP-2, MMP-9, and hs-CRP were compared before and after intervention with the use of statistical tests. RESULTS: The mean energy, carbohydrate, and protein intake of patients increased in the synbiotic group, while in the placebo group, post intervention, significant reduction was noticed in these parameters (P |
| Databáze: | OpenAIRE |
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