Effect of smoking on tuberculosis treatment outcomes: A systematic review and meta-analysis

Autor: Adamu Addissie, Berhe Dessalegn, Abay Burusie, Tafesse Lamaro, Fikre Enquesilassie
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Bacterial Diseases
RNA viruses
Epidemiology
Extensively Drug-Resistant Tuberculosis
Social Sciences
Cochrane Library
Pathology and Laboratory Medicine
Habits
Database and Informatics Methods
0302 clinical medicine
Mathematical and Statistical Techniques
Immunodeficiency Viruses
Medicine and Health Sciences
Smoking Habits
Psychology
030212 general & internal medicine
Database Searching
Multidisciplinary
Statistics
Metaanalysis
Treatment Outcome
Infectious Diseases
Medical Microbiology
Meta-analysis
Viral Pathogens
Physical Sciences
Viruses
Medicine
Pathogens
Research Article
HIV infections
Medical conditions
Funnel plot
Tuberculosis
Science
MEDLINE
Viral diseases
Research and Analysis Methods
Microbiology
03 medical and health sciences
Retroviruses
Tobacco Smoking
medicine
Humans
Statistical Methods
Microbial Pathogens
Behavior
Biology and life sciences
business.industry
Lentivirus
Organisms
Extensively drug-resistant tuberculosis
HIV
Publication bias
medicine.disease
Tropical Diseases
Confidence interval
030228 respiratory system
Medical Risk Factors
business
Mathematics
Demography
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239333 (2020)
ISSN: 1932-6203
Popis: IntroductionNumerous studies have explored an effect of cigarette smoking on tuberculosis treatment outcomes but with dissimilar conclusions.ObjectiveTo determine the effect of cigarette smoking on tuberculosis treatment outcomes.MethodsPubMed, Cochrane library and Google scholar databases were searched last on February 27, 2019. We applied the random-effects model for the analysis. Publication bias was assessed using funnel plot and Egger's regression. Furthermore, we performed Orwin's Fail-Safe N and cumulative meta-analysis to check for small studies' effect.ResultsOut of 22 studies we included in the qualitative synthesis, 12 studies reported p-values less than 0.05 where smoking significantly favored poor treatment outcomes. The remaining 10 studies reported p-values larger than 0.05 implying that smoking does not affect the treatment outcomes. Twenty studies met the criteria for inclusion in a meta-analysis. The meta-analysis found that smoking significantly increased the likelihood of poor tuberculosis treatment outcomes by 51% (OR = 1.51; 95% CI = 1.30 to 1.75 and I-square = 75.1%). In a sub-group analysis, the effect was higher for low- and middle-income countries (OR = 1.74; 95% CI = 1.31 to 2.30) and upper-middle-income economies (OR = 1.52; 95% CI = 1.16 to 1.98) than for high-income ones (OR = 1.34; 95% CI = 1.03 to 1.75) even though the differences in the effects among the strata were not statistically significant as demonstrated by overlapping of confidence intervals of the effects. Meta-regression analysis, adjusted for income economies, found the effect of smoking has not significantly improved over the years (p = 0.92) and thus implying neither of the covariates were source of the heterogeneity. Egger's regression test indicated that publication bias is unlikely (p = 0.403).ConclusionCigarette smoking is significantly linked with poor tuberculosis treatment outcomes.
Databáze: OpenAIRE
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