Calcium-mediated modulation of the quaternary structure and function of adenosine A2A–dopamine D2 receptor heteromers
| Autor: | Sergi Ferré, Carme Lluís, Gemma Navarro, M.S. Aymerich, Amina S. Woods, Rafael Franco |
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| Rok vydání: | 2010 |
| Předmět: |
Receptor
Adenosine A2A Calmodulin Heteromer Article Dopamine receptor D1 Dopamine receptor D2 Drug Discovery Enzyme-linked receptor medicine Humans 5-HT5A receptor Protein Structure Quaternary Pharmacology biology Receptors Dopamine D2 Chemistry Adenosine Cell biology Energy Transfer biology.protein Calcium Mitogen-Activated Protein Kinases Protein Multimerization Adenosine A2B receptor Protein Binding Signal Transduction medicine.drug |
| Zdroj: | Current Opinion in Pharmacology. 10:67-72 |
| ISSN: | 1471-4892 |
| DOI: | 10.1016/j.coph.2009.10.002 |
| Popis: | The adenosine A(2A)-dopamine D(2) receptor heteromer is one of the most studied receptor heteromers. It has important implications for basal ganglia function and pathology. Recent studies using Bioluminescence and Sequential Resonance Energy Transfer techniques shed light on the role of Ca(2+) in the modulation of the quaternary structure of the A(2A)-D(2) receptor heteromer, which was found to depend on the binding of calmodulin (CaM) to the carboxy-terminus of the A(2A) receptor in the A(2A)-D(2) receptor heteromer. Importantly, the changes in quaternary structure correlate with changes in function. A Ca(2+)/CaM-dependent modulation of MAPK signaling upon agonist treatment could be observed in cells expressing A(2A)-D(2) receptor heteromers. These studies provide a first example of a Ca(2+)-mediated modulation of the quaternary structure and function of a receptor heteromer. |
| Databáze: | OpenAIRE |
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