Behavioral deficits and neural damage of Caenorhabditis elegans induced by three rare earth elements
| Autor: | Defu He, Zihan Li, Lili Lei, Taipu Wu, Tiantian Xu, Jiani Hu, Jianing Bao, Siyu Wu, Manke Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Environmental Engineering Pharyngeal pumping Movement Health Toxicology and Mutagenesis Transgene Dendrite Environment 010501 environmental sciences 01 natural sciences Green fluorescent protein Toxicology 03 medical and health sciences medicine Animals Body Size Environmental Chemistry GABAergic Neurons Caenorhabditis elegans 0105 earth and related environmental sciences Neodymium biology Chemistry Dopaminergic Neurons Dopaminergic Public Health Environmental and Occupational Health Neurotoxicity Agriculture General Medicine General Chemistry biology.organism_classification medicine.disease Pollution Cell biology 030104 developmental biology medicine.anatomical_structure GABAergic Metals Rare Earth Praseodymium Scandium |
| Zdroj: | Chemosphere. 181:55-62 |
| ISSN: | 0045-6535 |
| Popis: | Rare earth elements (REEs) are widely used in industry, agriculture, medicine and daily life in recent years. However, environmental and health risks of REEs are still poorly understood. In this study, neurotoxicity of trichloride neodymium, praseodymium and scandium were evaluated using nematode Caenorhabditis elegans as the assay system. Median lethal concentrations (48 h) were 99.9, 157.2 and 106.4 mg/L for NdCl3, PrCl3 and ScCl3, respectively. Sublethal dose (10–30 mg/L) of these trichloride salts significantly inhibited body length of nematodes. Three REEs resulted in significant declines in locomotor frequency of body bending, head thrashing and pharyngeal pumping. In addition, mean speed and wavelength of crawling movement were significantly reduced after chronic exposure. Using transgenic nematodes, we found NdCl3, PrCl3 and ScCl3 resulted in loss of dendrite and soma of neurons, and induced down-expression of dat-1::GFP and unc-47::GFP. It indicates that REEs can lead to damage of dopaminergic and GABAergic neurons. Our data suggest that exposure to REEs may cause neurotoxicity of inducing behavioral deficits and neural damage. These findings provide useful information for understanding health risk of REE materials. |
| Databáze: | OpenAIRE |
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