The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder
| Autor: | E. Gene Stubbs, Adele Cutler, Alma Maciulis, Anthony R. Torres, Dennis Odell |
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| Rok vydání: | 2002 |
| Předmět: |
Proband
Genetics Genetic Linkage Immunology Pcr ssop HLA-DR Antigens General Medicine Human leukocyte antigen Transmission disequilibrium test Biology medicine.disease Linkage Disequilibrium Autism spectrum disorder mental disorders HLA-DR4 Antigen medicine Humans Immunology and Allergy Autism Autistic Disorder Allele Alleles HLA-DR Serological Subtypes |
| Zdroj: | Human Immunology. 63:311-316 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/s0198-8859(02)00374-9 |
| Popis: | We have evaluated possible contributions of HLA-DRB1 alleles to autism spectrum disorder (ASD) in 103 families of Caucasian descent. The DR4 allele occurred more often in probands than controls (0.007), whereas the DR13,14 alleles occurred less often in probands than controls (p = 0.003). The transmission disequilibrium test (TDT) indicated that the ASD probands inherited the DR4 allele more frequently than expected (p = 0.026) from the fathers. The TDT also revealed that fewer DR13 alleles than expected were inherited from the mother by ASD probands (p = 0.006). We conclude that the TDT results suggest that DR4 and DR13 are linked to ASD. Reasons for the parental inheritance of specific alleles are poorly understood but coincide with current genetic research noting possible parent-of-origin effects in autism. |
| Databáze: | OpenAIRE |
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