Principles of Intravascular Lithotripsy for Calcific Plaque Modification
| Autor: | Dean J. Kereiakes, Carlos Mena-Hurtado, Ziad A. Ali, Andrew Holden, Jason Y. Hokama, Sean P. Lyden, Jonathan Hill, Uday Illindala, Renu Virmani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Coronary Artery Disease 030204 cardiovascular system & hematology Lithotripsy Balloon Coronary artery disease 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Vascular Calcification Adverse effect business.industry Stent medicine.disease Peripheral Treatment Outcome Stents Radiology Delivery system Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | JACC: Cardiovascular Interventions. 14:1275-1292 |
| ISSN: | 1936-8798 |
| Popis: | A significant proportion of lesions treated with transcatheter interventions in the coronary and peripheral vascular beds exhibit moderate to severe calcific plaques known to portend lower procedural success rates, increased peri-procedural adverse events, and unfavorable clinical outcomes compared with noncalcific plaques. Adapted from lithotripsy technology used for treatment of ureterorenal calculi, intravascular lithotripsy (IVL) is a novel technique for the treatment of severely calcific plaque lesions that uses acoustic shockwaves in a balloon-based delivery system. Shockwaves induce calcium fractures, which facilitate stent expansion and luminal gain. In this review, the authors summarize the physics, preclinical and clinical data on IVL use in the coronary and peripheral vasculature, and future directions of IVL in transcatheter cardiovascular therapies. |
| Databáze: | OpenAIRE |
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