An Evaluation of the Collagen Fragments Related to Fibrogenesis and Fibrolysis in Nonalcoholic Steatohepatitis
Autor: | Kurex Sidik, Michael O. Idowu, Amon Asgharpour, Mohammed S. Siddiqui, Faridoddin Mirshahi, Melissa J. Contos, Robert Vincent, Rose C. Christian, Gabor Jarai, Edgar D. Charles, Arun J. Sanyal, Yi Luo, Rebeca Collen, Abdul M. Oseini, Robert C. Gagnon, Kalyani Daita, Glenn D. Rosen |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Biopsy lcsh:Medicine Inflammation Gastroenterology Severity of Illness Index Article 03 medical and health sciences 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Internal medicine Severity of illness medicine Humans Longitudinal Studies Stage (cooking) lcsh:Science Multidisciplinary medicine.diagnostic_test business.industry lcsh:R medicine.disease 030104 developmental biology Cross-Sectional Studies Cohort Biomarker (medicine) 030211 gastroenterology & hepatology Female lcsh:Q Collagen Steatosis medicine.symptom business Biomarkers |
Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Fibrosis, resulted from the imbalance of fibrogenesis and fibrolysis, is a key readout of disease progression in nonalcoholic steatohepatitis (NASH) and reflects mortality risk. Non-invasive biomarkers capable of diagnosing fibrosis stages and monitoring fibrosis changes in NASH patients are urgently needed. This study is to evaluate collagen formation and degradation biomarkers, reflective of fibrogenesis or fibrolysis, in patients with biopsy proven NASH. Collagen formation biomarker PRO-C3 and PRO-C6 levels were significantly higher in patients with advanced fibrosis stage 3–4 than those with fibrosis stage 0–2. Elevated PRO-C3 levels were also associated with severe lobular inflammation and ballooning, but not with steatosis. Multivariate logistic regression analysis identified PRO-C3 and PRO-C6 to be independently related to fibrosis stage. PRO-C3 showed similar performance to identify patients with advanced fibrosis in discovery and validation cohorts. Furthermore, in a longitudinal study cohort with paired biopsies, mean PRO-C3 increased with worsening of fibrosis and decreased with fibrosis improvement. The results suggest that PRO-C3 may be a potentially useful biomarker in identifying patients with advanced fibrosis and active fibrogenesis, as well as in assessing changes in fibrosis over time. It is worthy of further evaluation to confirm its diagnostic value and clinical utility. |
Databáze: | OpenAIRE |
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