Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells
| Autor: | Cheng Zhen Liang, Qixin Chen, Hao Li |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
Hypoxia-Inducible Factor 1 Pathology medicine.medical_specialty Cell Survival Review Article Biology Hypoxia inducible factor Extracellular matrix In vivo Basic Helix-Loop-Helix Transcription Factors medicine Animals Humans Intervertebral Disc Transcription factor intervertebral disc degeneration nucleus pulposus General Medicine Hypoxia (medical) musculoskeletal system Phenotype Extracellular Matrix Cell biology Repressor Proteins medicine.anatomical_structure Hypoxia-inducible factors medicine.symptom Apoptosis Regulatory Proteins Nucleus Orthopedics & Rehabilitation |
| Zdroj: | Yonsei Medical Journal |
| ISSN: | 1976-2437 0513-5796 |
| DOI: | 10.3349/ymj.2013.54.4.807 |
| Popis: | Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization of nucleus pulposus (NP) cells may be key contributors to progressive IVD degeneration. IVD is the largest avascular structure in the body, characterized by low oxygen tension in vivo. Hypoxia-inducible factor (HIF) is a master transcription factor that is induced upon hypoxia and directs coordinated cellular responses to hypoxic environments. This review summarizes relevant studies concerning the involvement of HIF in the regulation of biological behaviors of NP cells. We describe current data on the expression of HIF in NP cells and further discuss the various roles that HIF plays in the regulation of the phenotype, survival, metabolism, matrix production and dystrophic mineralization of NP cells. Here, we conclude that HIF may be a promising target for the prevention and treatment of IVD degeneration. |
| Databáze: | OpenAIRE |
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